SCHEMBL232127

SCHEMBL232127

C=CCN1C[C@H](C)N([C@H](c2ccc(C(=O)N(CC)CC)cc2)c2cccc(O)c2)C[C@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 1.00
CYP1A2 P05177 4/20 1.00
OPRD1 P41143 4/20 1.00
CYP2C9 P11712 3/20 1.00
HPGD P15428 3/20 1.00
OPRM1 P35372 2/20 1.00
OPRK1 P41145 2/20 1.00
SIGMAR1 Q99720 1/20 1.00
KDM4E B2RXH2 2/20 0.83
CYP2C19 P33261 2/20 0.83
MEN1 O00255 2/20 0.80
KMT2A Q03164 2/20 0.80
CYP2D6 P10635 2/20 0.80
LMNA P02545 1/20 0.80
BLM P54132 1/20 0.80
PMP22 Q01453 1/20 0.80
MAPT P10636 1/20 0.80
TDP1 Q9NUW8 1/20 0.80
NFKB1 P19838 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6934906 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL29457703 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL6933968 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL6557492 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL4575410 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL232128 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL4576328 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL232384 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL232385 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD
SCHEMBL12019442 1.00 CYP3A4 (1.00) CYP3A4CYP1A2OPRD1CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230158016-A1 DELTA OPIOID RECEPTOR ANTAGONISTS REPROGRAM IMMUNOSUPPRESSIVE MICROENVIRONMENT TO BOOST IMMUNOTHERAPY NATIONAL INSTITUTES OF HEALTH 2023-05-25 US claimed
US-20200289489-A1 COMBINATION FOR TREATING PAIN REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2020-09-17 US claimed
EP-3432884-A1 COMBINATION FOR TREATING PAIN Regents of the University of Minnesota (US) 2019-01-30 EP claimed
WO-2017165558-A1 COMBINATION FOR TREATING PAIN REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2017-09-28 WO claimed
US-20120004242-A1 Oligomer-Diarylpiperazine Conjugates NEKTAR THERAPEUTICS (US) 2012-01-05 US claimed
US-6300332-B1 DRUG MEDIATED RESPIRATORY DEPRESSION, MUSCLE RIGIDITY AND NAUSEA/VOMITING AND SIDE EFFECT REDUCTION DELTA PHARMACEUTICALS, INC. 2001-10-09 US claimed
EP-4704874-A2 MOLECULES AND METHODS OF USE THEREOF Woolwich Sciences LLC (US) 2026-03-11 EP disclosed
US-20260060822-A1 BIOENGINEERED SCAFFOLDS FOR VASCULAR GRAFTS AND METHODS OF USE THEREOF UNIV WAKE FOREST HEALTH SCIENCES (US) 2026-03-05 US disclosed
US-12527770-B2 Methods of managing pain using dexmedetomidine transdermal delivery devices TEIKOKU PHARMA USA, INC. (US) 2026-01-20 US disclosed
US-20250366978-A1 DEVICES AND METHODS OF MAKING AND USE THEREOF METHODIST HOSPITAL (US) 2025-12-04 US disclosed
US-20250366979-A1 DEVICES AND METHODS OF MAKING AND USE THEREOF METHODIST HOSPITAL (US) 2025-12-04 US disclosed
EP-4608374-A1 METHODS AND COMPOSITIONS COMPRISING FLT3L FOR THE TREATMENT OF WOUNDS The University of Chicago (US) 2025-09-03 EP disclosed
US-20250251323-A1 COLLECTION PROBE AND METHODS OF USE THEREOF BAYLOR COLLEGE OF MEDICINE 2025-08-07 US disclosed
EP-1003373-A1 COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS DELTA PHARMACEUTICALS, INC. (US) 2000-05-31 EP disclosed
US-5985880-A REDUCING, TREATING OR PREVENTING DRUG-MEDIATED RESPIRATORY DEPRESSION IN AN ANIMAL BY ADMINISTERING A .DELTA. RECEPTOR AGONIST COMPOUND DELTA PHARMACEUTICALS (US) 1999-11-16 US disclosed
WO-1999001033-A1 COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS DELTA PHARMACEUTICALS, INC. (US) 1999-01-14 WO disclosed
US-5854249-A Opioid diarylmethylpiperazines and piperidines DELTA PHARMACEUTICALS, INC. (US) 1998-12-29 US disclosed
US-5658908-A RECEPTOR BINDING SPECIES FOR MEDIATING ANALGESIA, COMBATTING DRUG ADDICTION, DRUG OVERDOSE DELTA PHARMACEUTICALS, INC. (US) 1997-08-19 US disclosed
EP-0649414-A1 OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES THE WELLCOME FOUNDATION LIMITED (GB) 1995-04-26 EP disclosed
WO-1993015062-A1 OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES THE WELLCOME FOUNDATION LIMITED (GB) 1993-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230158016-A1 DELTA OPIOID RECEPTOR ANTAGONISTS REPROGRAM IMMUNOSUPPRESSIVE MICROENVIRONMENT TO BOOST IMMUNOTHERAPY OPRD1, OPRM1, OPRK1 CYP3A4 3601/4885CYP1A2 2525/4885OPRD1 1/4885
US-20260060822-A1 BIOENGINEERED SCAFFOLDS FOR VASCULAR GRAFTS AND METHODS OF USE THEREOF PFKP, PBK, MYLK CYP3A4 2837/4885CYP1A2 2618/4885OPRD1 4518/4885
US-12527770-B2 Methods of managing pain using dexmedetomidine transdermal delivery devices OPRD1, OPRK1, OPRM1 CYP3A4 656/4885CYP1A2 249/4885OPRD1 1/4885
US-20200289489-A1 COMBINATION FOR TREATING PAIN OPRL1, ACHE, OPRK1 CYP3A4 2957/4885CYP1A2 1796/4885OPRD1 6/4885
US-20120004242-A1 Oligomer-Diarylpiperazine Conjugates BIRC5, MTX2, IAPP CYP3A4 771/4885CYP1A2 493/4885OPRD1 2294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.