Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330683 | 0.91 | ADORA2A (0.38) | IKBKBADORA2AIRAK4 | |
| SCHEMBL2331129 | 0.89 | RXRA (0.36) | IKBKBADORA2AKMT2ARXRARXRB | |
| SCHEMBL2324582 | 0.89 | IKBKB (0.39) | IKBKBADORA2AKMT2AKDM4EHSD17B10 | |
| SCHEMBL2330747 | 0.89 | IKBKB (0.44) | IKBKBADORA2AKMT2ARXRARXRB | |
| SCHEMBL2327822 | 0.89 | TRPM8 (0.36) | IKBKBADORA2AKDM4ESMN1; SMN2PIN1 | |
| SCHEMBL2332003 | 0.87 | FYN (0.39) | IKBKBADORA2AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2324749 | 0.85 | IKBKB (0.46) | IKBKBADORA2AKMT2ARXRARXRB | |
| SCHEMBL2327049 | 0.85 | IKBKB (0.48) | IKBKBADORA2AKMT2ARXRARXRB | |
| SCHEMBL2331664 | 0.83 | MAPK14 (0.34) | IKBKBHDAC6 | |
| SCHEMBL1704159 | 0.82 | IKBKB (0.44) | IKBKBADORA2AKMT2ARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |