Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 4/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 3/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324582 | 0.91 | IKBKB (0.39) | ADORA2ANR4A2IKBKBMEN1KMT2A | |
| SCHEMBL2327822 | 0.91 | TRPM8 (0.36) | ADORA2ASLC9A1IKBKBPIN1FPR2 | |
| SCHEMBL2330747 | 0.91 | IKBKB (0.44) | RXRARXRBRXRGADORA2ANR4A2 | |
| SCHEMBL2324316 | 0.89 | IKBKB (0.47) | RXRARXRBHDAC6ADORA2AIKBKB | |
| SCHEMBL2332003 | 0.89 | FYN (0.39) | ADORA2AIKBKBHSD17B1HSD17B2KDM4E | |
| SCHEMBL2330683 | 0.87 | ADORA2A (0.38) | ADORA2AIKBKBFPR2DHODHPPARG | |
| SCHEMBL2331664 | 0.85 | MAPK14 (0.34) | HDAC4HDAC1HDAC6IKBKB | |
| SCHEMBL2328930 | 0.84 | HCRTR1 (0.44) | RXRARXRBRXRGADORA2ANR4A2 | |
| SCHEMBL2328143 | 0.82 | RXRA (0.37) | RXRARXRBRXRGADORA2ANR4A2 | |
| SCHEMBL2131687 | 0.81 | FPR2 (0.39) | RXRARXRBRXRGHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |