Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331129 | 0.91 | RXRA (0.36) | IKBKBKMT2AMEN1RXRARXRB | |
| SCHEMBL2324582 | 0.90 | IKBKB (0.39) | IKBKBPOLBKMT2AMEN1NR4A2 | |
| SCHEMBL2327822 | 0.90 | TRPM8 (0.36) | IKBKBSMN1; SMN2SLC9A1PIN1ADORA2A | |
| SCHEMBL2324316 | 0.89 | IKBKB (0.47) | IKBKBNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2332003 | 0.89 | FYN (0.39) | IKBKBSMN1; SMN2ADORA2A | |
| SCHEMBL2330683 | 0.86 | ADORA2A (0.38) | IKBKBADORA2A | |
| SCHEMBL2331664 | 0.84 | MAPK14 (0.34) | IKBKB | |
| SCHEMBL2329257 | 0.84 | IKBKB (0.43) | IKBKBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2331266 | 0.84 | IKBKB (0.45) | IKBKBRAB9AKMT2AMEN1RXRA | |
| SCHEMBL1704456 | 0.81 | IKBKB (0.41) | IKBKBNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |