SCHEMBL23243909

SCHEMBL23243909

CC(C)C(=O)Nc1nc2c(ncn2[C@@H]2O[C@@](CO)(CO[Si](C(C)C)(C(C)C)C(C)C)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.48
▸ TAS1R3 Q7RTX0 1/20 0.45
▸ TAS1R1 Q7RTX1 1/20 0.45
▸ HINT1 P49773 4/20 0.37
▸ HPGD P15428 1/20 0.37
▸ TAAR1 Q96RJ0 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.36
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ IMPDH2 P12268 2/20 0.35
▸ IMPDH1 P20839 1/20 0.35
▸ POLA1 P09884 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ ADORA3 P0DMS8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27174748 0.91 KDM4E (0.51) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL23069358 0.90 KDM4E (0.48) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL23069327 0.83 TYMP (0.45) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL23069392 0.83 KDM4E (0.42) KDM4ETAS1R3TAS1R1HINT1TAAR1
SCHEMBL28515546 0.81 KDM4E (0.52) KDM4ETAS1R3TAS1R1HINT1TAAR1
SCHEMBL23243908 0.81 ADORA3 (0.46) ALDH1A1ADORA3
SCHEMBL23069365 0.80 KDM4E (0.52) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL22301414 0.80 KDM4E (0.49) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL22704912 0.79 KDM4E (0.51) KDM4ETAS1R3TAS1R1HINT1HPGD
SCHEMBL26534322 0.79 KDM4E (0.51) KDM4ETAS1R3TAS1R1HINT1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103480-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI SA (FR) 2026-04-16 — — US disclosed
CN-112105625-B Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same 赛诺菲 2024-12-31 — — CN disclosed
US-20240376137-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI SA (FR) 2024-11-14 — — US disclosed
US-20240092819-A1 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR SANOFI SA (FR) 2024-03-21 — — US disclosed
US-11897911-B2 Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same SANOFI (FR) 2024-02-13 — — US disclosed
EP-4232455-A2 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR Sanofi (FR) 2023-08-30 — — EP disclosed
CN-116368146-A Novel ligands for asialoglycoprotein receptors 赛诺菲 2023-06-30 — — CN disclosed
US-20220372063-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS SANOFI (FR) 2022-11-24 — — US disclosed
EP-4025582-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS SANOFI (FR) 2022-07-13 — — EP disclosed
WO-2022084331-A2 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR SANOFI (FR) 2022-04-28 — — WO disclosed
US-20210115075-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI (FR) 2021-04-22 — — US disclosed
CN-112105625-A Nucleotide precursors, nucleotide analogs, and oligomeric compounds containing the same 赛诺菲 2020-12-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11897911-B2 Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same RNMT, RRM2B, RRM2 KDM4E 3880/4885TAS1R3 3463/4885TAS1R1 2885/4885
US-20210115075-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME RNMT, RRM2B, RRM2 KDM4E 3880/4885TAS1R3 3463/4885TAS1R1 2885/4885
US-20260103480-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME NSUN2, NSUN3, SNRPA KDM4E 4376/4885TAS1R3 3302/4885TAS1R1 2475/4885
US-20240376137-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME RNMT, NSUN2, ADAR KDM4E 3599/4885TAS1R3 3532/4885TAS1R1 3167/4885
US-20220372063-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS DCLRE1B, UPF1, IGF2BP1 KDM4E 4002/4885TAS1R3 3924/4885TAS1R1 3586/4885
US-20240092819-A1 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR ASGR1, HAVCR2, SIGLEC7 KDM4E 3954/4885TAS1R3 2089/4885TAS1R1 1821/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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