Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241258 | 0.96 | ALDH1A1 (0.45) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL241257 | 0.96 | ALDH1A1 (0.45) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL10173733 | 0.96 | ALDH1A1 (0.45) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL1984645 | 0.88 | ALDH1A1 (0.39) | ALDH1A1PDE8BKMT2ATSHRMEN1 | |
| SCHEMBL1984642 | 0.88 | ALDH1A1 (0.39) | ALDH1A1PDE8BKMT2ATSHRMEN1 | |
| SCHEMBL18058877 | 0.84 | ALDH1A1 (0.43) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL18731202 | 0.81 | UCHL1 (0.43) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL15773460 | 0.81 | ALDH1A1 (0.44) | ALDH1A1PDE8BKMT2ATSHRMEN1 | |
| SCHEMBL28152177 | 0.81 | ALDH1A1 (0.44) | ALDH1A1PDE8BKMT2ATSHRMEN1 | |
| SCHEMBL18829051 | 0.80 | UCHL1 (0.41) | ALDH1A1KMT2ATSHRMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103459-A1 | SUBSTITUTED AZACYLES AS TRPM8 MODULATORS | GIVAUDAN SA (CH) | 2026-04-16 | — | — | US | disclosed |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | GIVAUDAN SA (CH) | 2026-01-20 | — | — | US | disclosed |
| EP-4192422-B1 | COOLING SENSATION COMPOSITIONS | GIVAUDAN SA (CH) | 2025-06-11 | — | — | EP | disclosed |
| EP-4192423-B1 | COOLING SENSATION COMPOSITIONS | GIVAUDAN SA (CH) | 2025-05-21 | — | — | EP | disclosed |
| US-20240139087-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | GIVAUDAN SA (CH) | 2024-05-02 | — | — | US | disclosed |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2024-04-25 | — | — | US | disclosed |
| EP-4291553-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | Givaudan SA (CH) | 2023-12-20 | — | — | EP | disclosed |
| CN-116867775-A | Organic compounds as TRPM8 activators | 奇华顿股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-20230310293-A1 | COOLING SENSATION COMPOSITIONS | GIVAUDAN SA (CH) | 2023-10-05 | — | — | US | disclosed |
| US-20230277427-A1 | COOLING SENSATION COMPOSITIONS | GIVAUDAN SA (CH) | 2023-09-07 | — | — | US | disclosed |
| EP-4192422-A1 | COOLING SENSATION COMPOSITIONS | Givaudan SA (CH) | 2023-06-14 | — | — | EP | disclosed |
| CN-116096347-A | Cooling composition | 奇华顿股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-116018128-A | Cooling composition | 奇华顿股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| EP-4045491-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | Givaudan SA (CH) | 2022-08-24 | — | — | EP | disclosed |
| WO-2022171653-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | GIVAUDAN SA (CH) | 2022-08-18 | — | — | WO | disclosed |
| CN-114555594-A | Substituted azaheterocycles as TRMP8 modulators | 奇华顿股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021074281-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2021-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103459-A1 | SUBSTITUTED AZACYLES AS TRPM8 MODULATORS | TRPM8, TRPM7, TRPM5 | ALDH1A1 1111/4885PDE8B 1233/4885KMT2A 2019/4885 |
| US-20230277427-A1 | COOLING SENSATION COMPOSITIONS | TRPA1, TRPV1, TRPV5 | ALDH1A1 1599/4885PDE8B 1447/4885KMT2A 3917/4885 |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | TRPM8, TRPM7, TRPM5 | ALDH1A1 871/4885PDE8B 546/4885KMT2A 741/4885 |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | TRPM8, TRPM7, TRPM4 | ALDH1A1 1465/4885PDE8B 1380/4885KMT2A 2021/4885 |
| US-20240139087-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | TRPM8, TRPM7, TRPM4 | ALDH1A1 1334/4885PDE8B 1860/4885KMT2A 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.