Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | ME2 | P23368 | 3/20 | 0.58 |
| ▸ | ME1 | P48163 | 3/20 | 0.58 |
| ▸ | ME3 | Q16798 | 3/20 | 0.58 |
| ▸ | AR | P10275 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23244270 | 1.00 | SIGMAR1 (0.64) | SIGMAR1ME2ME1ME3AR | |
| SCHEMBL23244239 | 0.83 | ME2 (0.58) | SIGMAR1ME2ME1ME3LMNA | |
| SCHEMBL3670009 | 0.77 | RAB9A (0.68) | SIGMAR1ME2ME1ME3AR | |
| SCHEMBL21551525 | 0.77 | ME2 (0.66) | ME2ME1ME3ALDH1A1LMNA | |
| SCHEMBL3669245 | 0.77 | ALDH1A1 (0.54) | SIGMAR1ARHRH3MEN1ALDH1A1 | |
| SCHEMBL23244366 | 0.76 | TDP1 (0.63) | ME2ME1ME3MEN1ALDH1A1 | |
| SCHEMBL29576883 | 0.76 | ME2 (0.58) | ME2ME1ME3 | |
| SCHEMBL23244158 | 0.76 | ME2 (0.58) | ME2ME1ME3 | |
| SCHEMBL3671122 | 0.76 | ALDH1A1 (0.53) | SIGMAR1ARHRH3MEN1ALDH1A1 | |
| SCHEMBL3666512 | 0.76 | RAB9A (0.60) | SIGMAR1ME2ME1ME3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-04-28 | — | — | US | disclosed |
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| WO-2021074898-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-04-22 | — | — | WO | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | SIGMAR1 4820/4885ME2 2/4885ME1 1/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | SIGMAR1 3067/4885ME2 3/4885ME1 1/4885 |
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | SIGMAR1 4820/4885ME2 2/4885ME1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.