Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817155 | 0.75 | ADORA3 (0.30) | — | |
| SCHEMBL8595494 | 0.75 | PLK1 (0.35) | — | |
| SCHEMBL3539990 | 0.71 | ALDH1A1 (0.35) | HTR7 | |
| SCHEMBL6131760 | 0.68 | PTGS2 (0.35) | HTR7 | |
| SCHEMBL3312444 | 0.66 | CYP19A1 (0.32) | CHRNB2CHRNA4 | |
| SCHEMBL7737037 | 0.65 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL5010291 | 0.65 | GAA (0.36) | CHRNB2CHRNA4 | |
| SCHEMBL4706494 | 0.64 | CHRNB2 (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL7152266 | 0.61 | PDE4B (0.36) | HTR1AHTR7 | |
| SCHEMBL2395150 | 0.61 | PLK1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588480-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF& xA; | SANOFI (FR) | 2013-05-08 | — | — | EP | disclosed |
| WO-2011161537-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-29 | — | — | WO | disclosed |