SCHEMBL23319971

SCHEMBL23319971

COC(=O)c1nnn(Cc2ccc(OC)cc2)c1Oc1ccc(-c2ccc(C3CC(F)(F)C3)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
AKR1C3 P42330 7/20 0.41
ERCC5 P28715 1/20 0.40
FEN1 P39748 1/20 0.40
CYP1A2 P05177 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
HSD17B10 Q99714 2/20 0.39
HPGD P15428 1/20 0.39
POLB P06746 3/20 0.39
MAPT P10636 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
METAP2 P50579 2/20 0.38
CNR2 P34972 1/20 0.37
MMP1 P03956 1/20 0.37
MMP2 P08253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26467810 0.94 CYP19A1 (0.39) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL26088232 0.93 S1PR4 (0.40) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL25465647 0.93 ALOX15 (0.41) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL25463564 0.92 KDM4E (0.45) ALOX15L3MBTL1MEN1KMT2ASMN1; SMN2
SCHEMBL26086645 0.91 ALOX15 (0.41) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL22816596 0.89 ALOX15 (0.42) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL25465471 0.86 CYP1A2 (0.41) ALOX15L3MBTL1AKR1C3ERCC5FEN1
SCHEMBL24155173 0.86 ALOX15 (0.41) ALOX15L3MBTL1MEN1KMT2AAKR1C3
SCHEMBL25465650 0.85 KDM4E (0.43) ALOX15L3MBTL1MEN1KMT2ASMN1; SMN2
SCHEMBL26467681 0.85 CYP19A1 (0.39) ALOX15L3MBTL1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114945559-B Preparation method of triazole glycollic acid oxidase inhibitor 坎特罗治疗有限公司 2025-03-11 CN disclosed
CN-112399873-B Triazole glycolate oxidase inhibitors 坎特罗治疗有限公司 2024-10-25 CN disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230129160-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-04-27 US disclosed
EP-4087836-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS Cantero Therapeutics, Inc. (US) 2022-11-16 EP disclosed
CN-114945559-A Preparation method of triazole glycolate oxidase inhibitor 坎特罗治疗有限公司 2022-08-26 CN disclosed
US-20210403439-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS VENTHERA, INC. 2021-12-30 US disclosed
EP-3817816-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS Orfan Biotech Inc. (US) 2021-05-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO ALOX15 71/4885L3MBTL1 2586/4885MEN1 3362/4885
US-20210403439-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO ALOX15 71/4885L3MBTL1 2586/4885MEN1 3362/4885
US-20230129160-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS TH, AOX1, AOC3 ALOX15 510/4885L3MBTL1 4348/4885MEN1 4709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.