Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323560 | 0.82 | P4HTM (0.38) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL3261360 | 0.75 | TRPM8 (0.38) | MAPTKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL16545869 | 0.75 | TDP1 (0.50) | P4HTMHDAC6MAPTKDM4EALDH1A1 | |
| SCHEMBL30503685 | 0.73 | KDM4E (0.43) | P4HTMNAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL29024939 | 0.73 | KDM4E (0.43) | P4HTMNAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL25932371 | 0.71 | P4HTM (0.36) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL25905786 | 0.71 | HCAR3 (0.61) | NAMPTHCAR3KDM4EALDH1A1POLB | |
| SCHEMBL25905785 | 0.71 | ADRA2A (0.40) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL25041234 | 0.70 | ADRA2A (0.44) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL22341854 | 0.68 | P4HTM (0.44) | P4HTMHDAC3HDAC1HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234929-A1 | RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| US-11566007-B2 | Ras inhibitors | Revolution Medicines, Inc. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210130303-A1 | RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566007-B2 | Ras inhibitors | KRAS, NRAS, HRAS | P4HTM 3119/4885NAMPT 2731/4885HDAC3 2510/4885 |
| US-20230234929-A1 | RAS INHIBITORS | KRAS, NRAS, HRAS | P4HTM 3119/4885NAMPT 2731/4885HDAC3 2510/4885 |
| US-20210130303-A1 | RAS INHIBITORS | KRAS, NRAS, HRAS | P4HTM 3119/4885NAMPT 2731/4885HDAC3 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.