Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23326983 | 0.80 | PTGDR2 (0.42) | — | |
| SCHEMBL21470647 | 0.79 | ESR2 (0.41) | HSP90AA1HSP90AB1ESR2 | |
| SCHEMBL27976940 | 0.71 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL6995541 | 0.68 | CHRNB2 (0.68) | CHRNB2CHRNA4ESR2ESR1 | |
| SCHEMBL2474344 | 0.68 | GRIN1 (0.42) | GRIN1GRIN2BHSP90AA1HSP90AB1TYR | |
| SCHEMBL4695695 | 0.68 | GRIN1 (0.37) | CHRNB2CHRNA4GRIN1GRIN2BHSP90AA1 | |
| SCHEMBL29655541 | 0.66 | CA12 (0.53) | ESR2ESR1CA2 | |
| SCHEMBL18711628 | 0.66 | SPR (0.44) | — | |
| SCHEMBL25320807 | 0.66 | PRMT5 (0.50) | GRIN2BHSP90AA1HSP90AB1ESR2ESR1 | |
| SCHEMBL25320802 | 0.66 | PRMT5 (0.50) | GRIN2BHSP90AA1HSP90AB1ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139484-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | GOSSAMER BIO SERVICES INC (US) | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139484-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | ULK1, PHKG2, PHKG1 | CHRNB2 2849/4885CHRNA4 2708/4885GRIN1 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.