Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22910629 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1HTTFFAR1 | |
| SCHEMBL14438291 | 0.88 | KDM4E (0.57) | SMN1; SMN2KDM4EALDH1A1HTTFFAR1 | |
| SCHEMBL23330025 | 0.86 | LMNA (0.57) | SMN1; SMN2KDM4EALDH1A1HTTPRMT6 | |
| SCHEMBL12890739 | 0.84 | ALDH1A1 (0.65) | SMN1; SMN2KDM4EALDH1A1HTTFFAR1 | |
| SCHEMBL23229951 | 0.83 | PRMT6 (0.59) | SMN1; SMN2KDM4EALDH1A1HTTFFAR1 | |
| SCHEMBL24061778 | 0.82 | KDM4E (0.49) | SMN1; SMN2KDM4EALDH1A1HTTFFAR1 | |
| SCHEMBL14438360 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1KMT2ASLC2A1 | |
| SCHEMBL2954251 | 0.78 | CASR (0.60) | SMN1; SMN2KDM4EALDH1A1HTTMEN1 | |
| SCHEMBL16301337 | 0.78 | ALDH1A1 (0.45) | SMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL14675911 | 0.77 | PRMT6 (0.69) | SLC2A1ROCK1ROCK2PRMT6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210130473-A1 | TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130473-A1 | TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF | TGFBR2, ASGR1, TGFBR1 | SMN1; SMN2 3891/4885KDM4E 3967/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.