Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23330026 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTKDM4EALDH1A1FFAR1 | |
| SCHEMBL23229951 | 0.81 | PRMT6 (0.59) | SMN1; SMN2HTTKDM4EALDH1A1FFAR1 | |
| SCHEMBL14438291 | 0.76 | KDM4E (0.57) | SMN1; SMN2HTTKDM4EALDH1A1FFAR1 | |
| SCHEMBL16301337 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL23330025 | 0.75 | LMNA (0.57) | SMN1; SMN2HTTKDM4EALDH1A1MAPK1 | |
| SCHEMBL12890739 | 0.72 | ALDH1A1 (0.65) | SMN1; SMN2HTTKDM4EALDH1A1FFAR1 | |
| SCHEMBL100121 | 0.72 | LOXL2 (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10223958 | 0.72 | TRPV6 (0.42) | SMN1; SMN2HTTKDM4EALDH1A1MEN1 | |
| SCHEMBL24061778 | 0.71 | KDM4E (0.49) | SMN1; SMN2HTTKDM4EALDH1A1FFAR1 | |
| SCHEMBL6204785 | 0.70 | TAAR1 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011834-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |