SCHEMBL23352192

SCHEMBL23352192

COc1ccc(C(O)c2cnc(Cl)s2)cc1-n1cccn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP9X Q93008 1/20 0.41
KMT2A Q03164 2/20 0.41
PSEN1 P49768 1/20 0.37
PSEN2 P49810 1/20 0.37
APH1B Q8WW43 1/20 0.37
NCSTN Q92542 1/20 0.37
APH1A Q96BI3 1/20 0.37
PSENEN Q9NZ42 1/20 0.37
KDM4E B2RXH2 2/20 0.37
NPBWR1 P48145 1/20 0.37
HPGD P15428 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CYP1A2 P05177 2/20 0.36
CYP2C19 P33261 2/20 0.36
RORC P51449 1/20 0.35
CYP2D6 P10635 1/20 0.35
EGLN1 Q9GZT9 2/20 0.34
KCNH2 Q12809 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23352236 0.92 USP9X (0.45) USP9XKMT2APSEN1PSEN2APH1B
SCHEMBL17758753 0.78 NOTUM (0.49) KMT2AKDM4ERORCMEN1ALDH1A1
SCHEMBL17758752 0.78 NOTUM (0.39) USP9XKMT2AKDM4ERORCMEN1
SCHEMBL23352193 0.76 LMNA (0.45) KMT2AKDM4EHPGDNPSR1CYP1A2
SCHEMBL20929575 0.76 HCRTR1 (0.40) KMT2AKDM4ENPBWR1HPGDNPSR1
SCHEMBL20929258 0.73 POLB (0.36) KMT2AKDM4ERORCMEN1ALDH1A1
SCHEMBL23352228 0.73 NOTUM (0.36) KMT2AKDM4EMEN1ALDH1A1MAPT
SCHEMBL30386383 0.70 ALDH1A1 (0.50) KMT2AKDM4EHPGDNPSR1CYP1A2
SCHEMBL23352235 0.70 MAPT (0.38) USP9XKMT2APSEN1PSEN2APH1B
SCHEMBL17758802 0.70 LMNA (0.39) KDM4ENPBWR1ALDH1A1MAPTHCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11459321-B2 Broad spectrum antiviral compositions and methods EVRYS BIO, LLC (US) 2022-10-04 US disclosed
US-20210139475-A1 Broad Spectrum Antiviral Compositions and Methods EVRYS BIO, LLC (US) 2021-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11459321-B2 Broad spectrum antiviral compositions and methods IRF3, MAVS, ZC3HAV1 USP9X 2449/4885KMT2A 2059/4885PSEN1 1394/4885
US-20210139475-A1 Broad Spectrum Antiviral Compositions and Methods MAVS, IRF3, ZC3HAV1 USP9X 2496/4885KMT2A 2333/4885PSEN1 1232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.