SCHEMBL2335970

SCHEMBL2335970

O=C(O)CCC(=O)SC(=O)CCC(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.60
EGLN1 Q9GZT9 3/20 0.60
ALKBH5 Q6P6C2 1/20 0.60
SUCNR1 Q9BXA5 1/20 0.60
SLC22A6 Q4U2R8 1/20 0.53
TSHR P16473 3/20 0.50
NFKB1 P19838 2/20 0.50
PMP22 Q01453 1/20 0.50
KMT2A Q03164 2/20 0.45
SLC15A2 Q16348 1/20 0.45
MAPK1 P28482 1/20 0.45
SLC13A3 Q8WWT9 1/20 0.45
OR51E2 Q9H255 1/20 0.45
HSD17B10 Q99714 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CAMK2A Q9UQM7 1/20 0.45
GABRR1 P24046 2/20 0.43
GABRR3 A8MPY1 1/20 0.43
GABRP O00591 1/20 0.43
GABRD O14764 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2340198 0.84 SLC22A6 (0.69) LMNAEGLN1ALKBH5SUCNR1SLC22A6
SCHEMBL9684944 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1SLC22A6
Succinic Acid SCHEMBL829 0.78
Succinic Acid SCHEMBL4269135 0.78 LMNA (1.00) LMNAEGLN1ALKBH5SUCNR1SLC22A6
Succinic Acid SCHEMBL4269130 0.78 LMNA (1.00) LMNAEGLN1ALKBH5SUCNR1SLC22A6
SCHEMBL24276585 0.78
Succinic Acid SCHEMBL1331200 0.78
Succinic Acid SCHEMBL3799615 0.78
Succinic Acid SCHEMBL21867134 0.78 LMNA (1.00) LMNAEGLN1ALKBH5SUCNR1SLC22A6
Succinic Acid SCHEMBL24696 0.78 LMNA (1.00) LMNAEGLN1ALKBH5SUCNR1SLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110301288-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP ASSETS B.V. (NL) 2011-12-08 US claimed
EP-2358668-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP Assets B.V. (NL) 2011-08-24 EP claimed
WO-2010070132-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP ASSETS B.V. (NL) 2010-06-24 WO claimed
EP-2199281-A1 Thioic acids as building block for polythioesters DSM IP Assets B.V. (NL) 2010-06-23 EP claimed
US-20110301288-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP ASSETS B.V. (NL) 2011-12-08 US disclosed
EP-2358668-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP Assets B.V. (NL) 2011-08-24 EP disclosed
WO-2010070132-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS DSM IP ASSETS B.V. (NL) 2010-06-24 WO disclosed
EP-2199281-A1 Thioic acids as building block for polythioesters DSM IP Assets B.V. (NL) 2010-06-23 EP disclosed
US-20090163697-A1 Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2009-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110301288-A1 THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS OXER1, OXGR1, HPD LMNA 2480/4885EGLN1 950/4885ALKBH5 2045/4885
US-20090163697-A1 Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides LNPEP, CLSPN, GALNT14 LMNA 1067/4885EGLN1 563/4885ALKBH5 2580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.