Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051488 | 0.82 | LMNA (0.49) | ALDH1A1GAAHTTLMNATSHR | |
| SCHEMBL2185384 | 0.78 | LMNA (0.46) | ALDH1A1LMNAPOLBTSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL9295868 | 0.78 | ATR (0.39) | KMT2AHTTLMNASMN1; SMN2HTR2B | |
| SCHEMBL1513840 | 0.75 | MEN1 (0.43) | ALDH1A1GAAKMT2AHPGDMEN1 | |
| SCHEMBL3496983 | 0.75 | LMNA (0.40) | ALDH1A1GAAHTTLMNAPOLB | |
| SCHEMBL2289311 | 0.73 | LMNA (0.39) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| Phosphoric Acid SCHEMBL1513833 | 0.71 | RAB9A (0.42) | ALDH1A1GAAKMT2AHPGDMEN1 | |
| SCHEMBL9296185 | 0.69 | PIN1 (0.37) | ALDH1A1GAAKMT2AHPGDMEN1 | |
| SCHEMBL25280719 | 0.68 | MAPT (0.47) | ALDH1A1GAAKMT2AHPGDMEN1 | |
| SCHEMBL9295725 | 0.66 | KMT2A (0.32) | ALDH1A1GAAKMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071761-B2 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-06 | — | — | US | disclosed |
| EP-1405922-B1 | Substrates for beta-lactamase and uses thereof | UNIV CALIFORNIA (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-09 | — | — | US | disclosed |
| US-7157575-B2 | Substrates for β-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-01-02 | — | — | US | disclosed |
| EP-1405922-A2 | Substrates for beta-lactamase and uses thereof | The Regents of the University of California (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-0982398-B1 | Nucleic acids and uses thereof for the assay of beta-lactamase | UNIV CALIFORNIA (US) | 2003-11-05 | — | — | EP | disclosed |
| US-20030119085-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-26 | — | — | US | disclosed |
| US-6472205-B1 | EXPRESSION CONTROL SEQUENCES ADAPTED FOR FUNCTION IN EUKARYOTIC CELL, OPERABLY LINKED TO SEQUENCE CODING CYTOSOLIC BETA-LACTAMASE; SCREENING BY CONTACTING HOST CELL WITH MEMBRANE PERMEABLE, FLUORESCENT SUBSTRATE OF BETA-LACTAMASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-10-29 | — | — | US | disclosed |
| US-6291162-B1 | DETERMINING AMOUNT OF LACTAMASE ACTIVITY; TRANSFECTING CELLS WITH A NUCLEIC ACID HAVING AN EXPRESSION CONTROL SEQUENCE LINKED TO A SECRETION DEFECTIVE SEQUENCE; MIXING CELLS WITH LACTAMASE SUBSTRATE; DETERMINE AMOUNT OF CLEAVED SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-09-18 | — | — | US | disclosed |
| EP-0817785-B1 | SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF | UNIV CALIFORNIA (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-0982398-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-03-01 | — | — | EP | disclosed |
| US-5955604-A | Substrates for β-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-21 | — | — | US | disclosed |
| US-5741657-A | MEASURING GENE EXPRESSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-21 | — | — | US | disclosed |
| EP-0817785-A2 | SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030540-A2 | SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119085-A1 | Substrates for beta-lactamase and uses thereof | CMBL, GLB1, BBOX1 | ALDH1A1 1448/4885GAA 196/4885KMT2A 1345/4885 |
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | CMBL, DBH, NCEH1 | ALDH1A1 1941/4885GAA 153/4885KMT2A 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.