SCHEMBL23453545

SCHEMBL23453545

CC(C)(C)OC(=O)N1CCC2CC2C1.F[B-](F)(F)F.F[B-](F)(F)F.F[B-](F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.54
JAK1 P23458 1/20 0.54
NR1H2 P55055 1/20 0.54
GPR119 Q8TDV5 10/20 0.47
HPGD P15428 1/20 0.46
RECQL P46063 1/20 0.43
EPHX1 P07099 1/20 0.43
PTPN2 P17706 1/20 0.43
PTPN1 P18031 1/20 0.43
PTPN6 P29350 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19389997 0.94 NR1H2 (0.59) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL23326893 0.89 NR1H2 (0.66) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL30733147 0.86 NR1H2 (0.55) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL31551882 0.85 GPR119 (0.59) NR1H2GPR119HPGDRECQLEPHX1
SCHEMBL12324579 0.85 JAK2 (0.54) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL12323272 0.85 JAK2 (0.54) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL10319836 0.85 JAK2 (0.54) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL10450115 0.85 JAK2 (0.54) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL31552172 0.84 NR1H2 (0.56) JAK2JAK1NR1H2GPR119HPGD
SCHEMBL15077744 0.82 JAK2 (0.52) JAK2JAK1NR1H2GPR119HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4384165-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS Janssen Pharmaceutica NV (BE) 2024-06-19 EP disclosed
US-11974987-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders JANSSEN PHARMACEUTICA NV (BE) 2024-05-07 US disclosed
US-11897891-B2 Tricyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-02-13 US disclosed
US-20230382902-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-11-30 US disclosed
US-20230365594-A1 THIENOPYRROLE COMPOUNDS GILEAD SCIENCES, INC. 2023-11-16 US disclosed
US-11806346-B2 HTT modulators for treating Huntington's disease CHDI FOUNDATION, INC. (US) 2023-11-07 US disclosed
US-11708359-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-07-25 US disclosed
US-11661431-B2 Thienopyrrole compounds GILEAD SCIENCES, INC. (US) 2023-05-30 US disclosed
US-20230117611-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS JANSSEN PHARMACEUTICA NV (BE) 2023-04-20 US disclosed
EP-4149937-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE CHDI Foundation, Inc. (US) 2023-03-22 EP disclosed
WO-2023019094-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS JANSSEN PHARMACEUTICA NV (BE) 2023-02-16 WO disclosed
US-20220409615-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE CHDI FOUNDATION, INC. 2022-12-29 US disclosed
EP-4103557-A1 MONOACYLGLYCEROL LIPASE MODULATORS Janssen Pharmaceutica NV (BE) 2022-12-21 EP disclosed
US-20220389034-A1 THIENOPYRROLE COMPOUNDS GILEAD SCIENCES, INC. 2022-12-08 US disclosed
WO-2021231571-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE CHDI FOUNDATION, INC. (US) 2021-11-18 WO disclosed
US-20210253565-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-08-19 US disclosed
WO-2021160602-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-08-19 WO disclosed
WO-2021113479-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION (US) 2021-06-10 WO disclosed
US-20210171535-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2021-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210253565-A1 MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, LIPC JAK2 4425/4885JAK1 4675/4885NR1H2 137/4885
US-20230365594-A1 THIENOPYRROLE COMPOUNDS SSB, TPMT, LCP2 JAK2 17/4885JAK1 176/4885NR1H2 1364/4885
US-11897891-B2 Tricyclic heterocycles as FGFR inhibitors FGFR3, FGFR1, FGFR2 JAK2 103/4885JAK1 231/4885NR1H2 2413/4885
US-11974987-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders LIPC, LPL, MGLL JAK2 4387/4885JAK1 4333/4885NR1H2 343/4885
US-20220409615-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, ATXN2 JAK2 3903/4885JAK1 4677/4885NR1H2 1722/4885
US-11708359-B2 Monoacylglycerol lipase modulators MGLL, LPL, LIPC JAK2 4425/4885JAK1 4675/4885NR1H2 137/4885
US-20230117611-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS LIPC, LPL, MGLL JAK2 4387/4885JAK1 4333/4885NR1H2 343/4885
US-20230382902-A1 MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, LIPC JAK2 4425/4885JAK1 4675/4885NR1H2 137/4885
US-11661431-B2 Thienopyrrole compounds SSB, TPMT, LCP2 JAK2 17/4885JAK1 176/4885NR1H2 1364/4885
US-11806346-B2 HTT modulators for treating Huntington's disease HTT, HYPK, ATXN2 JAK2 3903/4885JAK1 4677/4885NR1H2 1722/4885
US-20210171535-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR3, FGFR1, FGFR2 JAK2 103/4885JAK1 231/4885NR1H2 2413/4885
US-20220389034-A1 THIENOPYRROLE COMPOUNDS SSB, TPMT, LCP2 JAK2 17/4885JAK1 176/4885NR1H2 1364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.