Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043362 | 0.71 | ALDH1A1 (0.50) | KMT2ARAB9AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL23481299 | 0.71 | CCR1 (0.34) | KMT2ACCR1CCR5CCR8HDAC6 | |
| SCHEMBL30899605 | 0.71 | KCNJ1 (0.49) | KMT2ACYP2A6KCNJ1ALDH1A1 | |
| SCHEMBL23458043 | 0.71 | ELANE (0.39) | HDAC6CYP2A6KCNJ1ALDH1A1 | |
| SCHEMBL23458074 | 0.71 | CCR1 (0.34) | KMT2ACCR1CCR5CCR8HDAC6 | |
| SCHEMBL23458243 | 0.68 | GABRG2 (0.43) | RAB9ANPC1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL23457996 | 0.68 | GRIN2D (0.32) | KMT2ACCR1CCR5CCR8HDAC6 | |
| SCHEMBL23565263 | 0.67 | GPR119 (0.44) | KMT2ACCR1CCR5CCR8HDAC6 | |
| SCHEMBL6071352 | 0.65 | — | — | |
| SCHEMBL1699061 | 0.65 | ALDH1A1 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528784-B2 | Alkynyl-(heteroaryl)-carboxamide HCN1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2026-01-20 | — | — | US | disclosed |
| CN-114746408-B | Alkynyl- (heteroaryl) -carboxamide HCN1 inhibitors | 豪夫迈·罗氏有限公司 | 2025-02-14 | — | — | CN | disclosed |
| EP-4069685-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-10-12 | — | — | EP | disclosed |
| US-20220306607-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2022-09-29 | — | — | US | disclosed |
| CN-114746408-A | Alkynyl- (heteroaryl) -carboxamide HCN1 inhibitors | 豪夫迈·罗氏有限公司 | 2022-07-12 | — | — | CN | disclosed |
| WO-2021110574-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021110574-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12528784-B2 | Alkynyl-(heteroaryl)-carboxamide HCN1 inhibitors | HCN1, HCN2, HCN3 | KMT2A 3220/4885CCR1 59/4885CCR5 269/4885 |
| US-20220306607-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | HCN1, HCN2, HCN3 | KMT2A 1852/4885CCR1 1044/4885CCR5 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.