Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21978539 | 0.76 | ESR2 (0.50) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL4963197 | 0.76 | TP53 (0.58) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL29768506 | 0.76 | NPC1 (0.44) | GABRG2GABRB3GABRA5GABRA2ALDH1A1 | |
| SCHEMBL23458339 | 0.76 | NPC1 (0.44) | GABRG2GABRB3GABRA5GABRA2ALDH1A1 | |
| SCHEMBL12682937 | 0.75 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL2113181 | 0.75 | GABRA5 (0.49) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL5727138 | 0.75 | ALDH1A1 (0.48) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL21979193 | 0.74 | PDE4D (0.53) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL15167255 | 0.73 | RAB9A (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8558986 | 0.72 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528784-B2 | Alkynyl-(heteroaryl)-carboxamide HCN1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2026-01-20 | — | — | US | disclosed |
| CN-114746408-B | Alkynyl- (heteroaryl) -carboxamide HCN1 inhibitors | 豪夫迈·罗氏有限公司 | 2025-02-14 | — | — | CN | disclosed |
| US-20220306607-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2022-09-29 | — | — | US | disclosed |
| CN-114746408-A | Alkynyl- (heteroaryl) -carboxamide HCN1 inhibitors | 豪夫迈·罗氏有限公司 | 2022-07-12 | — | — | CN | disclosed |
| WO-2021110574-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021110574-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12528784-B2 | Alkynyl-(heteroaryl)-carboxamide HCN1 inhibitors | HCN1, HCN2, HCN3 | GABRG2 1913/4885GABRB3 1754/4885GABRA5 1654/4885 |
| US-20220306607-A1 | ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS | HCN1, HCN2, HCN3 | GABRG2 1269/4885GABRB3 1006/4885GABRA5 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.