Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRE | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175235 | 0.78 | MAPK1 (0.68) | MAPK1LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL3091100 | 0.72 | LMNA (0.64) | LMNAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14656717 | 0.71 | MAPK1 (0.42) | MAPK1LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL16968020 | 0.71 | MAPK1 (0.46) | MAPK1LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL2345107 | 0.71 | TSHR (0.39) | MAPK1LMNAGABRPGABRDGABRA1 | |
| SCHEMBL15330740 | 0.71 | KDM4E (0.47) | MAPK1LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL25342529 | 0.69 | NLRP3 (0.47) | MAPK1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL1270152 | 0.68 | MAPK1 (0.42) | MAPK1LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL2351094 | 0.68 | LMNA (0.45) | LMNAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2352509 | 0.68 | LMNA (0.45) | LMNAGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932835-B1 | METHOD FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2013-12-25 | — | — | EP | disclosed |
| EP-1930331-B1 | METHOD FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2013-03-13 | — | — | EP | disclosed |
| US-8334379-B2 | Process for producing imidazo[1,2-b]pyridazine compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-12-18 | — | — | US | disclosed |
| US-8008485-B2 | Process for producing 2,3-dihydropyridazine compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-30 | — | — | US | disclosed |
| US-20100234597-A1 | PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20090105475-A1 | PROCESS FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-04-23 | — | — | US | disclosed |
| EP-1932835-A1 | METHOD FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-06-18 | — | — | EP | disclosed |
| EP-1930331-A1 | METHOD FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105475-A1 | PROCESS FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND | DDC, DHPS, QDPR | MAPK1 230/4885LMNA 3177/4885GABRP 1446/4885 |
| US-20100234597-A1 | PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND | CYP1B1, CYP4Z1, CYP2J2 | MAPK1 581/4885LMNA 3651/4885GABRP 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.