SCHEMBL2349067

SCHEMBL2349067

O=Cc1cccc(Oc2ccccn2)c1

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TLR4 O00206 2/20 0.64
TLR2 O60603 2/20 0.64
MAOA P21397 7/20 0.50
MAOB P27338 7/20 0.50
ALDH1A1 P00352 3/20 0.48
POLB P06746 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
FFAR4 Q5NUL3 1/20 0.47
SRC P12931 1/20 0.45
GRM5 P41594 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
KDM4E B2RXH2 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
LMNA P02545 1/20 0.44
MAP4K4 O95819 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29612417 0.82 TLR4 (0.56) TLR4TLR2ALDH1A1POLBFFAR4
SCHEMBL12129555 0.82 TLR4 (0.56) TLR4TLR2ALDH1A1POLBFFAR4
SCHEMBL3933029 0.81 ALDH1A1 (0.66) TLR4TLR2MAOAMAOBALDH1A1
SCHEMBL31238491 0.81 ALDH1A1 (0.66) TLR4TLR2ALDH1A1POLBL3MBTL1
SCHEMBL510396 0.81 ALDH1A1 (0.66) TLR4TLR2ALDH1A1POLBL3MBTL1
SCHEMBL25401405 0.81 TLR4 (0.58) TLR4TLR2ALDH1A1L3MBTL1FFAR4
SCHEMBL15602369 0.81 TLR4 (0.55) TLR4TLR2ALDH1A1FFAR4GRM5
SCHEMBL10544371 0.80 TLR4 (0.56) TLR4TLR2ALDH1A1POLBL3MBTL1
SCHEMBL10545780 0.80 TLR4 (0.56) TLR4TLR2ALDH1A1POLBL3MBTL1
SCHEMBL18131575 0.79 TLR4 (1.00) TLR4TLR2MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 US disclosed
US-20240101579-A1 BORONIC ACID COMPOUNDS LG CHEM, LTD. (KR) 2024-03-28 US disclosed
EP-4242213-A1 BORONIC ACID COMPOUND Lg Chem, Ltd. (KR) 2023-09-13 EP disclosed
CN-116568310-A Boric acid compounds 株式会社LG化学 2023-08-08 CN disclosed
WO-2022123530-A1 BORONIC ACID COMPOUND 주식회사 엘지화학 2022-06-16 WO disclosed
WO-2022123530-A1 BORONIC ACID COMPOUND 주식회사 엘지화학 2022-06-16 WO disclosed
CN-107466290-B Substituted cyclic amides as herbicides FMC公司 2021-08-03 CN disclosed
EP-3280709-B1 SUBSTITUTED CYCLIC AMIDES AS HERBICIDES FMC CORP (US) 2021-05-26 EP disclosed
US-10405547-B2 Substituted cyclic amides as herbicides FMC CORPORATION (US) 2019-09-10 US disclosed
US-10377745-B2 Heterocyclic compounds as NaV channel inhibitors and uses thereof MERCK PATENT GMBH (DE) 2019-08-13 US disclosed
EP-1688138-A1 RECEPTOR FUNCTION REGULATING AGENT Takeda Pharmaceutical Company Limited (JP) 2006-08-09 EP disclosed
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor CHEN ZHAOGEN 2006-01-12 US disclosed
EP-1583759-A1 PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM ORION CORPORATION (FI) 2005-10-12 EP disclosed
WO-2004063191-A1 PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM ORION CORPORATION (FI) 2004-07-29 WO disclosed
EP-1379239-A2 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-14 EP disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 WO disclosed
EP-0436199-B1 Cyclopropyl derivative lipoxygenase inhibitors ABBOTT LAB (US) 1994-08-03 EP disclosed
US-5120752-A N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents ABBOTT LABORATORIES (US) 1992-06-09 US disclosed
US-5037853-A Antiinflammatory agents ABBOTT LABORATORIES (US) 1991-08-06 US disclosed
EP-0436199-A1 Cyclopropyl derivative lipoxygenase inhibitors ABBOTT LABORATORIES (US) 1991-07-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 TLR4 2938/4885TLR2 1648/4885MAOA 2010/4885
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor HTR6, HTR2C, HTR1B TLR4 2004/4885TLR2 942/4885MAOA 75/4885
US-20240101579-A1 BORONIC ACID COMPOUNDS PSMB11, PSMB1, BACH1 TLR4 2289/4885TLR2 1904/4885MAOA 2844/4885
US-10405547-B2 Substituted cyclic amides as herbicides CYP1A1, CYP1B1, QSOX1 TLR4 3620/4885TLR2 2454/4885MAOA 825/4885
US-10377745-B2 Heterocyclic compounds as NaV channel inhibitors and uses thereof CACNA1B, CACNG6, SCN5A TLR4 3399/4885TLR2 4423/4885MAOA 2038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.