Sugi Predict

Sugi Predict / Compounds / SCHEMBL2349201

SCHEMBL2349201

SCHEMBL2349201

COC(=O)c1nc(Br)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.47
▸ KDM4E B2RXH2 6/20 0.43
▸ PKM P14618 3/20 0.43
▸ RCE1 Q9Y256 1/20 0.43
▸ ALDH1A1 P00352 6/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ S1PR4 O95977 1/20 0.39
▸ NOTUM Q6P988 1/20 0.38
▸ GABRA2 P47869 1/20 0.38
▸ GABRB2 P47870 1/20 0.38
▸ LMNA P02545 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ TAS1R3 Q7RTX0 1/20 0.37
▸ TAS1R1 Q7RTX1 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3860719 0.82 NPSR1 (0.47) NPSR1KDM4EPKMRCE1ALDH1A1
SCHEMBL29829085 0.81 NPSR1 (0.50) NPSR1KDM4EALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL29679379 0.81 ALDH1A1 (0.51) NPSR1KDM4EPKMRCE1ALDH1A1
SCHEMBL5747714 0.81 NPSR1 (0.50) NPSR1KDM4EPKMALDH1A1L3MBTL1
SCHEMBL240027 0.81 ALDH1A1 (0.51) NPSR1KDM4EPKMRCE1ALDH1A1
SCHEMBL388845 0.81 NPSR1 (0.50) NPSR1KDM4EALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL16061031 0.81 ALDH1A1 (0.50) NPSR1KDM4EALDH1A1L3MBTL1GABRA2
SCHEMBL17753595 0.80 NPSR1 (0.48) NPSR1KDM4EPKMALDH1A1L3MBTL1
SCHEMBL610102 0.80 S1PR4 (0.56) NPSR1KDM4EPKMRCE1ALDH1A1
SCHEMBL1585112 0.79 KMT2A (0.36) KDM4EPKMALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114630822-B Biaryl dihydroorotate acid dehydrogenase inhibitors 詹森生物科技公司 2024-10-01 — — CN disclosed
US-20240158414-A1 BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH, INC. 2024-05-16 — — US disclosed
EP-3466934-B1 SULFONAMIDE COMPOUNDS OR SALT THEREOF AS RIBONUCLEOTIDE REDUCTASE INHIBITORS FOR TREATING CANCER TAIHO PHARMACEUTICAL CO LTD (JP) 2024-03-27 — — EP disclosed
EP-4041714-B1 BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH INC (US) 2023-12-13 — — EP disclosed
US-11634395-B2 Sulfonamide compound or salt thereof Taiho Pharmaceutial Co., Ltd. (JP) 2023-04-25 — — US disclosed
US-20230017045-A1 PYRIDINE AND PYRIMIDINE CARBOXYLATE HERBICIDES AND METHODS OF USE THEREOF DOW AGROSCIENCES LLC (US) 2023-01-19 — — US disclosed
EP-4041714-A1 BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS Janssen Biotech, Inc. (US) 2022-08-17 — — EP disclosed
CN-109563057-B Sulfonamide compound or salt thereof 大鹏药品工业株式会社 2022-06-24 — — CN disclosed
CN-114630822-A Biaryl dihydroorotate dehydrogenase inhibitors 詹森生物科技公司 2022-06-14 — — CN disclosed
WO-2021070132-A1 BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH, INC. (US) 2021-04-15 — — WO disclosed
US-8962529-B2 Substituted picolinic acids, salts and acid derivatives thereof, and use thereof as herbicides BAYER CROPSCIENCE AG (DE) 2015-02-24 — — US disclosed
WO-2014069510-A1 NOVEL AMINE DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2014-05-08 — — WO disclosed
US-20120157314-A1 NOVEL SUBSTITUTED PICOLINIC ACIDS, SALTS AND ACID DERIVATIVES THEREOF, AND USE THEREOF AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2012-06-21 — — US disclosed
EP-1498413-B1 4-Aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2011-08-31 — — EP disclosed
EP-1246802-B1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-03-14 — — EP disclosed
EP-1498413-A1 4-Aminopicolinates and their use as herbicides Dow AgroSciences LLC (US) 2005-01-19 — — EP disclosed
EP-1246802-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2002-10-09 — — EP disclosed
US-20010047099-A1 4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2001-11-29 — — US disclosed
US-6297197-B1 DEMONSTRATING A BROAD SPECTRUM OF WEED CONTROL. DOW AGROSCIENCES LLC 2001-10-02 — — US disclosed
WO-2001051468-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120157314-A1 NOVEL SUBSTITUTED PICOLINIC ACIDS, SALTS AND ACID DERIVATIVES THEREOF, AND USE THEREOF AS HERBICIDES HPD, ALAD, DDT NPSR1 506/4885KDM4E 3652/4885PKM 995/4885
US-20230017045-A1 PYRIDINE AND PYRIMIDINE CARBOXYLATE HERBICIDES AND METHODS OF USE THEREOF PDXK, DPYD, DDT NPSR1 2945/4885KDM4E 1143/4885PKM 1121/4885
US-20010047099-A1 4-aminopicolinates and their use as herbicides AADAT, ABAT, DDT NPSR1 1632/4885KDM4E 668/4885PKM 2448/4885
US-20240158414-A1 BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS DHODH, DLD, DPYD NPSR1 4442/4885KDM4E 1665/4885PKM 1789/4885
US-11634395-B2 Sulfonamide compound or salt thereof RNASEH1, SNRPA1, RRM2 NPSR1 353/4885KDM4E 1551/4885PKM 3945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.