Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 7/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422338 | 0.88 | POLB (0.80) | POLBCTDSP1MAPTMEN1KMT2A | |
| SCHEMBL422339 | 0.88 | POLB (0.80) | POLBCTDSP1MAPTMEN1KMT2A | |
| Galioside SCHEMBL29431810 | 0.78 | POLB (1.00) | POLBCTDSP1MAPTMEN1KMT2A | |
| Gardenoside SCHEMBL306407 | 0.78 | POLB (1.00) | POLBCTDSP1MAPTMEN1KMT2A | |
| Pelargonidin SCHEMBL6072597 | 0.72 | POLB (0.57) | POLBCTDSP1MAPTKDM4EHSP90AA1 | |
| Lactulose SCHEMBL10380730 | 0.72 | MEN1 (0.67) | POLBCTDSP1MAPTMEN1KMT2A | |
| SCHEMBL29426021 | 0.71 | POLB (0.69) | POLBCTDSP1HSP90AA1 | |
| SCHEMBL29751499 | 0.71 | POLB (0.57) | POLBCTDSP1MAPTKDM4EGLA | |
| Gardenoside SCHEMBL6824467 | 0.69 | POLB (0.78) | POLBCTDSP1MAPTMEN1KMT2A | |
| Ribose (Furanose) SCHEMBL3976341 | 0.68 | LMNA (0.54) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210177879-A1 | VITAMIN D RECEPTOR AGONIST | GUANGZHOU UNIVERSITY OF CHINESE MEDICINE (CN) | 2021-06-17 | — | — | US | disclosed |