Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2350878 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5152411 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5152407 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2350866 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2350870 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917909 | 0.97 | ALDH1A1 (0.52) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL3410259 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL1519018 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917912 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917905 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113113233-A | Solid-liquid mixed winding type aluminum electrolytic capacitor and preparation method thereof | 深圳市金富康电子有限公司 | 2021-07-13 | — | — | CN | claimed |
| EP-1519972-B2 | COMPOSITIONS FOR PRODUCING AMINOPLAST PRODUCTS AND METHOD FOR PRODUCING PRODUCTS FROM THESE COMPOSITIONS | BOREALIS AGROLINZ MELAMINE (AT) | 2011-08-24 | — | — | EP | claimed |
| EP-1159334-B1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GEN ELECTRIC (US) | 2007-01-17 | — | — | EP | claimed |
| EP-1519972-B1 | COMPOSITIONS FOR PRODUCING AMINOPLAST PRODUCTS AND METHOD FOR PRODUCING PRODUCTS FROM THESE COMPOSITIONS | AMI AGROLINZ MELAMINE INT GMBH (AT) | 2006-10-25 | — | — | EP | claimed |
| US-20050250896-A1 | Compositions for producing aminoplast products and method for producing products from these compositions | AMI-AGROLINZ MELAMINE INTERNATIONAL GMBH (AT) | 2005-11-10 | — | — | US | claimed |
| US-6417274-B1 | OXIDATIVE COUPLING IN SOLUTION OF MONOVLENT PHENOL USING OXYGEN CONTAINING GAS; CATALYSIS WITH METAL COMPLEX; FUNCTIONALIZING POLYPHENYLENE ETHER DURING ISOLATION STEP FOR DEVOLATILIZATION | GENERAL ELECTRIC CO. | 2002-07-09 | — | — | US | claimed |
| EP-0250979-B1 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GEN ELECTRIC (US) | 1993-10-20 | — | — | EP | claimed |
| US-4889889-A | BLENDS WITH POLYAMIDE, POLYESTERS | GENERAL ELECTRIC COMPANY (US) | 1989-12-26 | — | — | US | claimed |
| EP-0250979-A2 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GENERAL ELECTRIC COMPANY (US) | 1988-01-07 | — | — | EP | claimed |
| JP-11186109-A | — | — | None | — | — | JP | disclosed |
| CN-120865671-A | SIS soap-free emulsion and preparation method and application thereof | 北京化工大学 | 2025-10-31 | — | — | CN | disclosed |
| CN-120535851-A | Soap-free emulsion of diene liquid rubber and preparation method and application thereof | 北京化工大学 | 2025-08-26 | — | — | CN | disclosed |
| US-20250174409-A1 | SOLID ELECTROLYTE CAPACITOR AND METHOD FOR MANUFACTURING SAME | CARLIT CO., LTD. (JP) | 2025-05-29 | — | — | US | disclosed |
| US-20250046527-A1 | ELECTROLYTIC CAPACITOR | NIPPON CHEMI-CON CORPORATION (JP) | 2025-02-06 | — | — | US | disclosed |
| EP-0033213-A2 | Pigment dispersions containing copolymer pigment dispersants and methods of grinding pigment dispersions | HÜLS AMERICA INC. (a Delaware corporation) (US) | 1981-08-05 | — | — | EP | disclosed |
| US-3963730-A | ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-06-15 | — | — | US | disclosed |
| US-3959295-A | ACETONE WITH AMMONIA, ACID CATALYSTS | CIBA-GEIGY CORPORATION (US) | 1976-05-25 | — | — | US | disclosed |
| US-3959298-A | ACETONINE WITH WATER IN ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-05-25 | — | — | US | disclosed |
| US-3953459-A | Process for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine | CIBA-GEIGY CORPORATION (US) | 1976-04-27 | — | — | US | disclosed |
| US-3940353-A | Pigment dispersions and lacquers containing copolymer of isobornyl methacrylate | ROHM AND HAAS COMPANY (US) | 1976-02-24 | — | — | US | disclosed |