Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2350878 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5152411 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL2350872 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2350866 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2350870 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917909 | 0.97 | ALDH1A1 (0.52) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL3410259 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL1519018 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917912 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL4917905 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159334-B1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GEN ELECTRIC (US) | 2007-01-17 | — | — | EP | claimed |
| US-6417274-B1 | OXIDATIVE COUPLING IN SOLUTION OF MONOVLENT PHENOL USING OXYGEN CONTAINING GAS; CATALYSIS WITH METAL COMPLEX; FUNCTIONALIZING POLYPHENYLENE ETHER DURING ISOLATION STEP FOR DEVOLATILIZATION | GENERAL ELECTRIC CO. | 2002-07-09 | — | — | US | claimed |
| EP-0250979-B1 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GEN ELECTRIC (US) | 1993-10-20 | — | — | EP | claimed |
| US-4889889-A | BLENDS WITH POLYAMIDE, POLYESTERS | GENERAL ELECTRIC COMPANY (US) | 1989-12-26 | — | — | US | claimed |
| EP-0250979-A2 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GENERAL ELECTRIC COMPANY (US) | 1988-01-07 | — | — | EP | claimed |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| EP-3518881-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| EP-3518879-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| EP-3518878-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| EP-3518889-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| EP-0747438-A2 | Compatible compositions of poly(phenylene ether) resins and polyester resins | GENERAL ELECTRIC COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747439-A2 | Reinforced compositions of poly(phenylene ether) and polyamide resins | GENERAL ELECTRIC COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0732369-A2 | Compositions of poly(phenylene ether), poly(arylene sulfide) polyester resins, and a compatibilizer compound | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732371-A2 | Composition of poly(phenylene ether), poly(arylene sulfide) and maleimide compounds | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732368-A2 | Flame retarded compositions of poly(phenylene ether), poly (arylene sulfide) and siloxane copolymer resins | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732370-A2 | Poly(phenylene ether) compositions | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0550210-A1 | Polyphenylene ether/polyamide compositions | GENERAL ELECTRIC COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550206-A2 | Polyphenylene ether/polyamide compositions | GENERAL ELECTRIC COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | ALDH1A1 1010/4885TSHR 3146/4885TP53 2105/4885 |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, SRRM2, IK | ALDH1A1 3629/4885TSHR 1850/4885TP53 2548/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | ALDH1A1 1179/4885TSHR 2235/4885TP53 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.