Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353940 | 0.92 | GRIA2 (0.48) | ADRA1DSLC10A2GRIA2KDM4EPOLB | |
| SCHEMBL2353944 | 0.92 | GRIA2 (0.44) | ADRA1DSLC10A2SIGMAR1CA2RYR2 | |
| SCHEMBL2356821 | 0.85 | GRIA2 (0.44) | ADRA1DSLC10A2GRIA2POLBMAPT | |
| SCHEMBL2357565 | 0.83 | GRIA2 (0.43) | ADRA1DSLC10A2GRIA2GALR1 | |
| SCHEMBL2353968 | 0.83 | GRIA2 (0.47) | ADRA1DGRIA2POLB | |
| SCHEMBL2351722 | 0.82 | MAOA (0.35) | ADRA1DGRIA2MAPT | |
| SCHEMBL2352846 | 0.82 | ADRA1D (0.42) | ADRA1DSLC10A2GRIA2 | |
| SCHEMBL2354383 | 0.81 | CA1 (0.36) | ADRA1DCA2GRIA2NOS3NOS1 | |
| SCHEMBL2357409 | 0.80 | GRIA2 (0.35) | ADRA1DSLC10A2GRIA2KDM4EGALR1 | |
| SCHEMBL2355589 | 0.78 | ADRA1D (0.40) | ADRA1DCA2GRIA2ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083264-A1 | THIOCHROMAN DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2011-07-14 | — | — | WO | claimed |
| WO-2011083264-A1 | THIOCHROMAN DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2011-07-14 | — | — | WO | disclosed |