Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.42 |
| ▸ | VEGFA | P15692 | 2/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357565 | 0.88 | GRIA2 (0.43) | ADRA1DGRIA2SLC10A2 | |
| SCHEMBL2353944 | 0.88 | GRIA2 (0.44) | ADRA1DGRIA2SLC10A2 | |
| SCHEMBL2351722 | 0.87 | MAOA (0.35) | ADRA1DGRIA2 | |
| SCHEMBL2355589 | 0.84 | ADRA1D (0.40) | ADRA1DGRIA2 | |
| SCHEMBL2353940 | 0.83 | GRIA2 (0.48) | ADRA1DGRIA2SLC10A2 | |
| SCHEMBL2357409 | 0.82 | GRIA2 (0.35) | ADRA1DVEGFASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2353218 | 0.82 | ADRA1D (0.46) | ADRA1DGRIA2SLC10A2 | |
| SCHEMBL2354007 | 0.77 | MMP2 (0.46) | ADRA1DMMP2ALDH1A1 | |
| SCHEMBL2347270 | 0.73 | GRIA1 (0.35) | ADRA1DGRIA2ALDH1A1 | |
| SCHEMBL2354383 | 0.73 | CA1 (0.36) | ADRA1DGRIA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083264-A1 | THIOCHROMAN DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2011-07-14 | — | — | WO | disclosed |