Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6074396 | 0.98 | LGMN (0.57) | LGMNKEAP1ADRA2CKMT2AMEN1 | |
| SCHEMBL14804198 | 0.81 | ADRB1 (0.50) | LGMNKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL14336963 | 0.79 | ALDH1A1 (0.45) | LGMNKMT2AMEN1GAAPOLB | |
| SCHEMBL22053011 | 0.79 | LGMN (0.44) | LGMNKMT2AMEN1GAAPOLB | |
| SCHEMBL14117670 | 0.79 | ADRB1 (0.51) | LGMNKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL23043597 | 0.78 | KEAP1 (0.62) | LGMNKEAP1ADRA2CKMT2AMEN1 | |
| SCHEMBL6132755 | 0.78 | ADRB1 (0.51) | ALDH1A1LMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL4555529 | 0.78 | LGMN (0.50) | LGMNKMT2APOLBALDH1A1PTPN11 | |
| SCHEMBL10481994 | 0.77 | SLC6A2 (0.43) | LGMNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL23152040 | 0.77 | ADRA2C (0.79) | LGMNKEAP1ADRA2CKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |