Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536626 | 0.73 | HSD11B1 (0.46) | HSD11B1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL23536541 | 0.67 | RORC (0.37) | PDE4AHSD11B1TRPV1MAPT | |
| SCHEMBL23536303 | 0.67 | MAPK14 (0.40) | MEN1KMT2AHTTTP53SMN1; SMN2 | |
| SCHEMBL23536536 | 0.63 | HSD11B1 (0.40) | PDE4AHSD11B1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL23536641 | 0.62 | HTT (0.46) | MEN1KMT2AHTTTP53SMN1; SMN2 | |
| SCHEMBL23570345 | 0.62 | ALDH1A1 (0.44) | HSD11B1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL23536665 | 0.61 | KDM4E (0.41) | HSD11B1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL21262632 | 0.61 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2MAPTTSHRMAPK1 | |
| SCHEMBL29931843 | 0.60 | MAPK14 (0.35) | MEN1KMT2ASMN1; SMN2MAPK14MAPT | |
| SCHEMBL12263172 | 0.58 | OPRK1 (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |