Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29714915 | 1.00 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAAAK1GPBAR1XDH | |
| SCHEMBL8378409 | 0.79 | PDK1 (0.41) | SMN1; SMN2GAAGPBAR1ALDH1A1KMT2A | |
| SCHEMBL31289612 | 0.77 | MAPK3 (0.37) | SMN1; SMN2GAAAAK1XDHNOS3 | |
| SCHEMBL31223908 | 0.77 | XDH (0.33) | SMN1; SMN2GAAAAK1XDHNOS3 | |
| SCHEMBL21741858 | 0.74 | KDM4E (0.44) | GAAXDHNOS3NOS1NOS2 | |
| SCHEMBL596048 | 0.74 | GAA (0.38) | SMN1; SMN2GAAAAK1XDHNOS3 | |
| SCHEMBL6555780 | 0.70 | MAPT (0.44) | SMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL9131221 | 0.69 | GAA (0.47) | SMN1; SMN2GAAGPBAR1ALDH1A1MEN1 | |
| SCHEMBL7983296 | 0.68 | RIPK1 (0.41) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL914446 | 0.68 | CRHR1 (0.41) | SMN1; SMN2ALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492172-B2 | Substituted quinazolinyl compounds useful as T cell activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-12-09 | — | — | US | disclosed |
| EP-4081516-B1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2025-07-30 | — | — | EP | disclosed |
| US-20230094758-A1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-03-30 | — | — | US | disclosed |
| EP-4081516-A1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | Bristol-Myers Squibb Company (US) | 2022-11-02 | — | — | EP | disclosed |
| CN-114846007-A | Substituted quinazolinyl compounds useful as T cell activators | 百时美施贵宝公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021133751-A1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
| WO-2021133751-A1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492172-B2 | Substituted quinazolinyl compounds useful as T cell activators | DGKZ, DGKA, DGKK | SMN1; SMN2 4748/4885GAA 1734/4885AAK1 219/4885 |
| US-20230094758-A1 | SUBSTITUTED QUINAZOLINYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKZ, DGKA, DGKK | SMN1; SMN2 4748/4885GAA 1734/4885AAK1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.