Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601745 | 0.90 | ABCG2 (0.36) | SIGMAR1ABCG2PDGFRBPDE5AEGFR | |
| SCHEMBL23600997 | 0.88 | PDGFRB (0.34) | ABCG2PDGFRBPDE5AEGFRKDR | |
| SCHEMBL23601204 | 0.80 | KDM4C (0.38) | MEN1MAPTKMT2AABCG2PDE5A | |
| SCHEMBL23601333 | 0.78 | ADORA3 (0.35) | MEN1LMNAKMT2AABCG2PDE5A | |
| SCHEMBL23601809 | 0.78 | LMNA (0.41) | TSHRLMNAMAPTPDGFRBPDE5A | |
| SCHEMBL23600980 | 0.78 | EGFR (0.36) | TP53LMNAMAPTABCG2PDGFRB | |
| SCHEMBL23601124 | 0.76 | KDM4E (0.37) | TP53CYP2D6TSHRMAPTKMT2A | |
| SCHEMBL23601734 | 0.76 | PDE5A (0.34) | PDE5AEGFR | |
| SCHEMBL23601500 | 0.75 | KCNA3 (0.32) | MEN1KMT2APDE5A | |
| SCHEMBL23601069 | 0.75 | PDE5A (0.37) | MAPTPDGFRBPDE5AEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |