Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10615422 | 1.00 | ALDH1A1 (0.72) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL1595963 | 0.85 | KMT2A (0.56) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL30216480 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL4861809 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL392680 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL478614 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7840775 | 0.83 | ALDH1A1 (0.97) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL13659482 | 0.83 | POLB (0.63) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL6692611 | 0.82 | POLB (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL11463170 | 0.82 | POLB (1.00) | ALDH1A1GAAPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787761-B2 | Process for the synthesis of Melphalan | INDENA S.P.A. (IT) | 2023-10-17 | — | — | US | disclosed |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-09-14 | — | — | US | disclosed |
| WO-2021130163-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787761-B2 | Process for the synthesis of Melphalan | PAH, TYR, MARS1 | ALDH1A1 2246/4885GAA 2121/4885POLB 1783/4885 |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, TYR, IL4I1 | ALDH1A1 2234/4885GAA 2092/4885POLB 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.