Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TTPA | P49638 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2140140 | 0.83 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL11701054 | 0.83 | PSEN1 (0.56) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL2140130 | 0.83 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL4592776 | 0.82 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL6597291 | 0.82 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL7843126 | 0.75 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL11440558 | 0.75 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL29670864 | 0.75 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL11440561 | 0.75 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL10546031 | 0.75 | PSEN1 (0.45) | PSEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303506-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-09-28 | — | — | US | disclosed |
| US-11584728-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210206736-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303506-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885EPHX2 2938/4885PTGS1 682/4885 |
| US-11584728-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | PSEN1 285/4885EPHX2 2938/4885PTGS1 682/4885 |
| US-20210206736-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885EPHX2 2938/4885PTGS1 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.