Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283973 | 0.94 | TRPM8 (0.48) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL8410197 | 0.76 | TRPM8 (0.49) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL2364276 | 0.75 | TRPM8 (0.41) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL15882569 | 0.74 | TRPM8 (0.48) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL29455981 | 0.73 | TRPM8 (0.47) | TRPM8SIGMAR1PPARGPPARA | |
| SCHEMBL3519974 | 0.73 | TRPM8 (0.47) | TRPM8SIGMAR1PPARGPPARA | |
| SCHEMBL17476110 | 0.73 | TRPM8 (0.41) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL4551228 | 0.72 | TRPM8 (0.46) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL6467973 | 0.71 | SIGMAR1 (0.45) | TRPM8SIGMAR1EPHX2EPHX1DRD2 | |
| SCHEMBL462820 | 0.71 | SIGMAR1 (0.45) | TRPM8SIGMAR1EPHX2EPHX1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296505-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2017-10-19 | — | — | US | disclosed |
| US-9676744-B2 | Long-chain carboxychromanols and analogs for use as anti-inflammatory agents | PURDUE RESEARCH FOUNDATION (US) | 2017-06-13 | — | — | US | disclosed |
| US-20150073044-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-03-12 | — | — | US | disclosed |
| US-8822529-B2 | Long-chain carboxychromanols and analogs for use as anti-inflammatory agents | PURDUE RESEARCH FOUNDATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-20110207808-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2011-08-25 | — | — | US | disclosed |
| WO-2010033687-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207808-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | ALOX12, ALOX5, ALOX15 | ADRA1D 1576/4885ADRA1A 929/4885ADRA1B 1592/4885 |
| US-20150073044-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | ALOX12, ALOX5, PTGS1 | ADRA1D 1793/4885ADRA1A 1201/4885ADRA1B 1866/4885 |
| US-20170296505-A1 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS | ALOX12, ALOX5, PTGS1 | ADRA1D 1793/4885ADRA1A 1201/4885ADRA1B 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.