Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | RNF4 | P78317 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502742 | 0.76 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTSMN1; SMN2HPGD | |
| SCHEMBL11134234 | 0.74 | TGM2 (0.43) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL9813659 | 0.69 | ALDH1A1 (0.60) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL11237117 | 0.69 | MTNR1A (0.54) | ALDH1A1GAAMAPTSMN1; SMN2POLB | |
| SCHEMBL22017029 | 0.68 | XDH (0.37) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL2369659 | 0.67 | TGM2 (0.49) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL4653369 | 0.65 | HPGD (0.70) | TGM2ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20819430 | 0.64 | SMN1; SMN2 (0.33) | ALDH1A1GAAMAPTSMN1; SMN2L3MBTL1 | |
| Acrylic Acid SCHEMBL28690059 | 0.62 | TGM2 (0.55) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL11394952 | 0.62 | NPC1 (0.66) | TGM2ALDH1A1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9867805-B2 | Gelatinase inhibitors and prodrugs | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160346247-A1 | GELATINASE INHIBITORS AND PRODRUGS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-12-01 | — | — | US | disclosed |
| US-8937151-B2 | Gelatinase inhibitors and prodrugs | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130052184-A1 | GELATINASE INHIBITORS AND PRODRUGS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2011109767-A2 | GELATINASE INHIBITORS AND PRODRUGS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130052184-A1 | GELATINASE INHIBITORS AND PRODRUGS | MMP14, MMP9, MMP10 | TGM2 674/4885ALDH1A1 325/4885GAA 113/4885 |
| US-20160346247-A1 | GELATINASE INHIBITORS AND PRODRUGS | MMP14, MMP9, MMP10 | TGM2 674/4885ALDH1A1 325/4885GAA 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.