Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | OGG1 | O15527 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13710935 | 1.00 | ROCK2 (0.48) | ROCK2SYKTRPM8PARP1OGG1 | |
| SCHEMBL13707887 | 0.84 | ALDH1A1 (0.49) | SYKTRPM8PARP1OGG1ADRA1D | |
| SCHEMBL17664005 | 0.84 | S1PR3 (0.49) | SYKTRPM8PARP1OGG1ADRA1D | |
| SCHEMBL13710921 | 0.81 | SYK (0.47) | ROCK2SYKPARP1ACP3 | |
| SCHEMBL7397371 | 0.81 | S1PR3 (0.47) | SYKTRPM8PARP1ADRA1DKEAP1 | |
| SCHEMBL13710925 | 0.80 | HDAC4 (0.50) | ROCK2PARP1 | |
| SCHEMBL23716167 | 0.79 | FFAR2 (0.47) | ROCK2ADRB2 | |
| SCHEMBL13710920 | 0.79 | L3MBTL1 (0.57) | ROCK2TRPM8PARP1 | |
| SCHEMBL5089604 | 0.78 | LMNA (0.44) | — | |
| SCHEMBL10090088 | 0.78 | LMNA (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |