SCHEMBL2371623

SCHEMBL2371623

[CH2]NS(=O)(=O)c1c(Cl)cccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.46
SLC1A3 P43003 1/20 0.45
SLC1A2 P43004 1/20 0.45
GAA P10253 2/20 0.44
MCL1 Q07820 1/20 0.44
SLC40A1 Q9NP59 1/20 0.44
CNR1 P21554 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
LMNA P02545 2/20 0.40
PKM P14618 1/20 0.40
ALDH1A1 P00352 3/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ITGAV P06756 1/20 0.39
CCR4 P51679 1/20 0.38
AKR1B1 P15121 1/20 0.37
POLB P06746 1/20 0.36
SLC16A3 O15427 1/20 0.36
NR3C1 P04150 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2372660 0.86 SLC40A1 (0.50) ATMSLC1A3SLC1A2GAAMCL1
SCHEMBL2371950 0.86 PKM (0.47) ATMSLC1A3SLC1A2GAAMCL1
SCHEMBL2371569 0.82 NFE2L2 (0.40) ATMPKMALDH1A1CCR4CYP1A2
SCHEMBL420192 0.77 SLC1A3 (0.49) ATMSLC1A3SLC1A2GAAMCL1
SCHEMBL1767985 0.77 ATM (0.50) ATMSLC1A3SLC1A2GAAMCL1
SCHEMBL2371626 0.77 ATM (0.50) ATMSLC1A3SLC1A2GAAMCL1
SCHEMBL2372744 0.77 PTGES2 (0.54) SLC40A1CCR4PGR
SCHEMBL2371933 0.76 ALDH1A1 (0.53) SLC1A3SLC1A2GAAMCL1SLC40A1
SCHEMBL132296 0.72 ATM (0.62) ATMGAAMCL1SLC40A1LMNA
SCHEMBL4033114 0.72 SLC1A3 (0.53) ATMSLC1A3SLC1A2GAAMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST ATM 3017/4885SLC1A3 4334/4885SLC1A2 3431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.