SCHEMBL2371569

SCHEMBL2371569

[CH2]NS(=O)(=O)c1c(Cl)cccc1OC

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 4/20 0.40
CCR4 P51679 3/20 0.40
KCNH2 Q12809 1/20 0.39
MAPK1 P28482 1/20 0.39
TSHR P16473 2/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 2/20 0.38
ATM Q13315 1/20 0.38
HTR6 P50406 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
PKM P14618 1/20 0.38
CYP2C19 P33261 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
ACHE P22303 1/20 0.37
PTGES2 Q9H7Z7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2371571 0.85 L3MBTL1 (0.42) NFE2L2CCR4KCNH2MAPK1TSHR
SCHEMBL2371623 0.82 ATM (0.46) CCR4MAPK1ALDH1A1ATMCYP1A2
SCHEMBL31650151 0.79 TRPV4 (0.44) NFE2L2KCNH2MAPK1TSHRHTR6
SCHEMBL15461574 0.79 NFE2L2 (0.44) NFE2L2KCNH2MAPK1HTR6CA1
SCHEMBL10296029 0.77 NFE2L2 (0.43) NFE2L2KCNH2MAPK1ALDH1A1CYP3A4
SCHEMBL2372660 0.77 SLC40A1 (0.50) ALDH1A1ATMPKM
Hydrochloric Acid SCHEMBL27288340 0.76 NFE2L2 (0.42) NFE2L2KCNH2MAPK1ALDH1A1CYP3A4
SCHEMBL2371950 0.74 PKM (0.47) TSHRALDH1A1ATMPKMPTGES2
SCHEMBL2371547 0.72 HTR6 (0.55) NFE2L2TSHRNPC1HTR6PKM
SCHEMBL669662 0.71 L3MBTL1 (0.49) MAPK1ALDH1A1HTR6CYP3A4CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST NFE2L2 38/4885CCR4 4805/4885KCNH2 3085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.