Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | CTSA | P10619 | 4/20 | 0.44 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373467 | 0.90 | DHODH (0.52) | DHODHCTSARORBMAPTMEN1 | |
| SCHEMBL2373302 | 0.89 | RORB (0.42) | CTSARORBMAPTMEN1KMT2A | |
| SCHEMBL2373266 | 0.86 | DHODH (0.47) | DHODHCTSARORBMAPTMEN1 | |
| SCHEMBL2372676 | 0.84 | DHODH (0.49) | DHODHCTSAMAPTMEN1KMT2A | |
| SCHEMBL2373595 | 0.84 | DHODH (0.45) | DHODHCTSARORBMAPTMEN1 | |
| SCHEMBL2373099 | 0.83 | KDM4E (0.47) | DHODHCTSAMAPTMEN1KMT2A | |
| SCHEMBL2372609 | 0.82 | DHODH (0.53) | DHODHKDM4EGAAPDE10APTGFR | |
| SCHEMBL2373263 | 0.82 | TRPV4 (0.49) | DHODHMAPTMEN1KMT2AKDM4E | |
| SCHEMBL2372892 | 0.81 | DHODH (0.44) | DHODHCTSAMAPTMEN1KMT2A | |
| SCHEMBL2373280 | 0.81 | DHODH (0.44) | DHODHMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |