Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461669 | 0.78 | HCAR3 (0.39) | HCAR3HCAR2ALDH1A1KDRGALR3 | |
| SCHEMBL25329372 | 0.65 | ALDH1A1 (0.38) | ALDH1A1GALR3OPRM1OPRL1CACNA1F | |
| SCHEMBL19691189 | 0.62 | ALDH1A1 (0.41) | ALDH1A1POLBMEN1KMT2ALMNA | |
| Butane SCHEMBL27384864 | 0.61 | ALDH1A1 (0.61) | ALDH1A1EPHX1TAS1R3TAS1R1MAOB | |
| SCHEMBL5045630 | 0.61 | NOS2 (0.32) | ALDH1A1POLBOPRM1 | |
| SCHEMBL31575815 | 0.59 | LMNA (0.60) | ALDH1A1USP2TAS1R3TAS1R1KDR | |
| SCHEMBL20267329 | 0.59 | LMNA (0.60) | ALDH1A1USP2TAS1R3TAS1R1KDR | |
| SCHEMBL15821917 | 0.58 | CES2 (0.47) | ALDH1A1EPHX1TAS1R3TAS1R1HDAC3 | |
| SCHEMBL14939165 | 0.57 | MAPT (0.49) | HCAR3HCAR2MAOBGALR3OPRM1 | |
| SCHEMBL13386454 | 0.57 | KDM1A (0.51) | HCAR3HCAR2HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |