Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25327896 | 0.85 | OPRM1 (0.46) | ALDH1A1MAPTBRD4GAAKDM4E | |
| SCHEMBL27313017 | 0.71 | BRD4 (0.45) | ALDH1A1MAPTBRD4GAAKDM4E | |
| SCHEMBL14893687 | 0.70 | OPRM1 (0.51) | OPRM1OPRD1OPRK1 | |
| SCHEMBL27870437 | 0.70 | BRD4 (0.55) | ALDH1A1MAPTBRD4GAAOPRM1 | |
| Hydrochloric Acid SCHEMBL11114651 | 0.69 | OPRM1 (0.65) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7961399 | 0.68 | ALDH1A1 (0.41) | ALDH1A1GAACACNA1FCACNA1DCACNA1S | |
| SCHEMBL11141405 | 0.66 | HCAR3 (0.41) | ALDH1A1MAPTGAAKDM4ETP53 | |
| SCHEMBL22915221 | 0.66 | ALDH1A1 (0.46) | ALDH1A1MAPTBRD4GAAKDM4E | |
| SCHEMBL11140391 | 0.65 | THRB (0.38) | ALDH1A1MAPTGAAKDM4ECACNA1F | |
| SCHEMBL2373128 | 0.65 | HCAR3 (0.34) | ALDH1A1OPRM1GALR3CACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12109207-B2 | Methods of using 4(1H)-quinolone derivatives | ACADEMIA SINICA (TW) | 2024-10-08 | — | — | US | disclosed |
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | ACADEMIA SINICA (TW) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12109207-B2 | Methods of using 4(1H)-quinolone derivatives | TUBB1, TUBB3, TUBB | ALDH1A1 1707/4885MAPT 144/4885BRD4 751/4885 |
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | TUBB1, TUBB3, TUBB | ALDH1A1 1707/4885MAPT 144/4885BRD4 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.