SCHEMBL2373247

SCHEMBL2373247

COC(=O)c1ncccc1N(CC(F)F)S(=O)(=O)Cc1ccccc1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 1/20 0.38
ABL1 P00519 1/20 0.38
SRC P12931 1/20 0.38
BMP1 P13497 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PTK2 Q05397 1/20 0.36
NFE2L2 Q16236 3/20 0.36
KIF11 P52732 1/20 0.36
RBP4 P02753 1/20 0.36
PARP1 P09874 1/20 0.36
SGMS2 Q8NHU3 1/20 0.35
ADAMTS4 O75173 1/20 0.35
MMP13 P45452 1/20 0.35
SLC22A12 Q96S37 1/20 0.35
PIK3C3 Q8NEB9 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90B1 P14625 1/20 0.35
RORC P51449 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KEAP1 Q14145 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL270665 0.88 BMP1 (0.38) GRM4ABL1SRCBMP1SMN1; SMN2
SCHEMBL165699 0.85 GRM4 (0.38) GRM4ABL1SRCBMP1PTK2
SCHEMBL14461317 0.83 RORC (0.33) SMN1; SMN2PTK2PARP1RORCL3MBTL1
SCHEMBL167188 0.80 TDP1 (0.38) GRM4ABL1SRCSMN1; SMN2NFE2L2
SCHEMBL272014 0.79 NR1H2 (0.40)
SCHEMBL271254 0.79 GRM4 (0.38) GRM4ABL1SRCBMP1SMN1; SMN2
SCHEMBL9957557 0.78 GRM4 (0.45) GRM4ABL1SRCBMP1NFE2L2
SCHEMBL271470 0.77 NFE2L2 (0.33) BMP1SMN1; SMN2PTK2NFE2L2KIF11
SCHEMBL12296770 0.77 ALDH1A1 (0.32) NFE2L2PARP1L3MBTL1KEAP1
SCHEMBL269838 0.76 POLQ (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2550280-B1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2014-02-26 EP disclosed
US-8440594-B2 Pyridothiazines having herbicidal action BASF SE (DE) 2013-05-14 US disclosed
EP-2550280-A1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2013-01-30 EP disclosed
US-20130005575-A1 Pyridothiazines Having Herbicidal Action BASF SE (DE) 2013-01-03 US disclosed
WO-2011117152-A1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2011-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130005575-A1 Pyridothiazines Having Herbicidal Action PNPO, PDXK, PLPBP GRM4 1003/4885ABL1 471/4885SRC 3677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.