Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TK1 | P04183 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26550486 | 0.88 | ALDH1A1 (0.44) | ALDH1A1CYP2C19SMN1; SMN2TK1MET | |
| SCHEMBL10137841 | 0.85 | SMN1; SMN2 (0.41) | ALDH1A1CYP2C19SMN1; SMN2TK1MET | |
| SCHEMBL22381003 | 0.82 | ALDH1A1 (0.43) | ALDH1A1CYP2C19SMN1; SMN2TK1DAO | |
| SCHEMBL24235951 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1CYP2C19SMN1; SMN2MET | |
| SCHEMBL4484823 | 0.81 | GAA (0.51) | ALDH1A1CYP2C19SMN1; SMN2METGAA | |
| SCHEMBL24564759 | 0.73 | SMN1; SMN2 (0.42) | ALDH1A1CYP2C19SMN1; SMN2TK1MET | |
| SCHEMBL22327058 | 0.72 | CYP2C19 (0.37) | ALDH1A1CYP2C19SMN1; SMN2METJAK2 | |
| SCHEMBL21637955 | 0.71 | SMN1; SMN2 (0.36) | ALDH1A1CYP2C19SMN1; SMN2METDAO | |
| SCHEMBL18858876 | 0.71 | MET (0.39) | ALDH1A1CYP2C19SMN1; SMN2METDAO | |
| SCHEMBL35260 | 0.71 | SMN1; SMN2 (0.42) | CYP2C19SMN1; SMN2TK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-06-29 | — | — | US | disclosed |
| US-20230028359-A1 | NUCLEOTIDE ANALOGUES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-01-26 | — | — | US | disclosed |
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | POLRMT, RNGTT, MTR | ALDH1A1 3268/4885CYP2C19 3791/4885SMN1; SMN2 4165/4885 |
| US-20230028359-A1 | NUCLEOTIDE ANALOGUES | ITPA, POLB, NUDT1 | ALDH1A1 1313/4885CYP2C19 2483/4885SMN1; SMN2 1787/4885 |
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | ITPA, POLB, NUDT1 | ALDH1A1 1313/4885CYP2C19 2483/4885SMN1; SMN2 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.