Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20093445 | 0.89 | EGFR (0.50) | EGFRERBB2SRCPIK3CDABL1 | |
| SCHEMBL13293328 | 0.80 | ERBB2 (0.56) | EGFRERBB2 | |
| SCHEMBL19414295 | 0.80 | SRC (0.47) | EGFRSRCPIK3CDABL1HCK | |
| SCHEMBL20093481 | 0.77 | KMO (0.46) | EGFRSRCPIK3CDABL1HCK | |
| SCHEMBL17626717 | 0.76 | PIK3CD (0.47) | EGFRERBB2PIK3CDKDRPIK3CA | |
| SCHEMBL17626654 | 0.74 | NUDT14 (0.48) | EGFRPIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL217790 | 0.73 | ABL1 (0.49) | EGFRSRCPIK3CDABL1HCK | |
| SCHEMBL11214 | 0.73 | DYRK1A (0.48) | EGFRSRCPIK3CDABL1HCK | |
| SCHEMBL11306 | 0.73 | SRC (0.47) | EGFRSRCPIK3CDABL1HCK | |
| SCHEMBL16783578 | 0.72 | PIK3CD (0.53) | SRCPIK3CDABL1HCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3398950-B1 | NOVEL KINASE INHIBITOR AGAINST WILD-TYPE EGFR AND MUTATED EGFR | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-08-11 | — | — | EP | disclosed |