Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739920 | 0.90 | HTR1A (0.42) | MEN1KMT2AHTR1ADRD2HTR6 | |
| SCHEMBL23739853 | 0.87 | HTR7 (0.43) | MEN1KMT2APARP2HTR1ADRD2 | |
| SCHEMBL24160437 | 0.87 | NPSR1 (0.39) | MEN1KMT2ANPSR1POLBKDM4E | |
| SCHEMBL23739600 | 0.87 | KDM4E (0.40) | MEN1KMT2ANPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL23739905 | 0.87 | DRD2 (0.45) | HTR1ADRD2HTR6 | |
| SCHEMBL23739497 | 0.86 | THRB (0.33) | MEN1KMT2APOLBKDM4E | |
| SCHEMBL23739669 | 0.86 | DRD2 (0.37) | HTR1ADRD2HTR6 | |
| SCHEMBL23739676 | 0.85 | HTR1A (0.44) | KDM4EHTR1ADRD2HTR6 | |
| SCHEMBL23739671 | 0.85 | ADRA1B (0.40) | MEN1KMT2ACNR1HTR1ADRD2 | |
| SCHEMBL23739921 | 0.85 | DRD2 (0.41) | HTR1ADRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |