Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 8/20 | 0.31 |
| ▸ | BRAF | P15056 | 8/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770751 | 0.82 | GPR119 (0.40) | RAF1BRAF | |
| SCHEMBL19925200 | 0.82 | LMNA (0.35) | ABL1RAF1BRAF | |
| SCHEMBL23770707 | 0.80 | AGPAT2 (0.39) | ABL1AGPAT2PDE2ABRAF | |
| SCHEMBL23770831 | 0.80 | ABL1 (0.33) | ABL1AGPAT2 | |
| SCHEMBL23770866 | 0.77 | SOS1 (0.34) | RAF1BRAF | |
| SCHEMBL23770741 | 0.76 | ABL1 (0.35) | ABL1AGPAT2RAF1BRAF | |
| SCHEMBL23770471 | 0.75 | SOS1 (0.34) | — | |
| SCHEMBL23770808 | 0.74 | HTR3E (0.38) | ABL1 | |
| SCHEMBL23770855 | 0.74 | ABL1 (0.32) | ABL1 | |
| SCHEMBL23770564 | 0.73 | SOS1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |