SCHEMBL2379396

SCHEMBL2379396

Cc1cn([C@H]2C[C@H](O)[C@@H](C(ON=[N+]=[N-])OP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.56
POLA1 P09884 1/20 0.56
POLD1 P28340 1/20 0.56
TK1 P04183 6/20 0.48
LMNA P02545 2/20 0.45
TSHR P16473 2/20 0.45
ALB P02768 1/20 0.45
PKM P14618 1/20 0.45
BLM P54132 1/20 0.45
PMP22 Q01453 1/20 0.45
CYP2D6 P10635 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9011028 0.91 TK1 (0.53) POLBPOLA1POLD1TK1LMNA
SCHEMBL10684890 0.83 POLB (0.54) POLBPOLA1POLD1TK1
SCHEMBL6910401 0.83 POLB (0.54) POLBPOLA1POLD1TK1
SCHEMBL9814884 0.82 TK1 (0.42) POLBPOLA1POLD1TK1LMNA
SCHEMBL9814768 0.82 TK1 (0.42) POLBPOLA1POLD1TK1LMNA
SCHEMBL4596737 0.81 TK1 (0.55) POLBTK1LMNATSHRALB
SCHEMBL9814738 0.81 TK1 (0.41) POLBPOLA1POLD1TK1LMNA
SCHEMBL9814855 0.80 TK1 (0.41) POLBPOLA1POLD1TK1LMNA
SCHEMBL9814737 0.80 TK1 (0.41) POLBPOLA1POLD1TK1LMNA
SCHEMBL9814872 0.80 TK1 (0.41) POLBPOLA1POLD1TK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2892509-B1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2024-12-11 EP disclosed
US-20220249539-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC 2022-08-11 US disclosed
US-11304964-B2 Bolaamphiphilic compounds, compositions and uses thereof LAUREN SCIENCES LLC (US) 2022-04-19 US disclosed
US-20220072098-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC 2022-03-10 US disclosed
EP-2892511-B1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2021-06-30 EP disclosed
US-10378006-B2 Near-infrared ray exposure system for biological studies THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2019-08-13 US disclosed
US-20190216895-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2019-07-18 US disclosed
US-20180305679-A1 NEAR-INFRARED RAY EXPOSURE SYSTEM FOR BIOLOGICAL STUDIES THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2018-10-25 US disclosed
EP-3283060-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF Lauren Sciences LLC (US) 2018-02-21 EP disclosed
US-20180021368-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2018-01-25 US disclosed
US-20160367678-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2016-12-22 US disclosed
WO-2016168580-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2016-10-20 WO disclosed
US-20160279069-A1 MATERIALS AND METHODS FOR SUSTAINED RELEASE OF ACTIVE COMPOUNDS THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2016-09-29 US disclosed
US-20150306236-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC 2015-10-29 US disclosed
EP-2892510-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF Lauren Sciences LLC (US) 2015-07-15 EP disclosed
US-20150110875-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2015-04-23 US disclosed
US-20150104502-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC 2015-04-16 US disclosed
WO-2014039501-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LAUREN SCIENCES LLC (US) 2014-03-13 WO disclosed
US-20110213193-A1 Magnetic Nanodelivery of Therapeutic Agents Across the Blood Brain Barrier THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2011-09-01 US disclosed
EP-0286418-B1 ANTI-RETROVIRAL AGENTS AND DELIVERY SYSTEMS FOR THE SAME US COMMERCE (US) 1992-07-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150104502-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF LGALS1, BOLA2; BOLA2B, LGALS2 POLB 4471/4885POLA1 3710/4885POLD1 4792/4885
US-20180021368-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF BOLA2; BOLA2B, LGALS1, LGALS2 POLB 4657/4885POLA1 4048/4885POLD1 4844/4885
US-20190216895-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF GFRA2, GFRA1, NGF POLB 4699/4885POLA1 4389/4885POLD1 4865/4885
US-11304964-B2 Bolaamphiphilic compounds, compositions and uses thereof LGALS1, BOLA2; BOLA2B, LGALS2 POLB 4471/4885POLA1 3710/4885POLD1 4792/4885
US-20220072098-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF GFRA2, GFRA1, NGF POLB 4709/4885POLA1 4376/4885POLD1 4864/4885
US-20160367678-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF GFRA2, GFRA1, NGF POLB 4741/4885POLA1 4483/4885POLD1 4868/4885
US-20150306236-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF BOLA2; BOLA2B, LGALS1, LGALS2 POLB 4657/4885POLA1 4048/4885POLD1 4844/4885
US-20150110875-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF GFRA2, GFRA1, NGF POLB 4709/4885POLA1 4376/4885POLD1 4864/4885
US-20220249539-A1 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF BOLA2; BOLA2B, LGALS1, LGALS2 POLB 4657/4885POLA1 4048/4885POLD1 4844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.