Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8776350 | 0.82 | NPC1 (0.37) | PNMTNPC1RAB9APGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL9069125 | 0.79 | SRD5A2 (0.38) | PNMTNPC1RAB9APGRCYP1A2 | |
| SCHEMBL7913219 | 0.78 | PNMT (0.36) | PNMTNPC1RAB9APGRCYP17A1 | |
| SCHEMBL3687435 | 0.78 | PNMT (0.33) | PNMTNPC1RAB9APGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL27425148 | 0.78 | PNMT (0.42) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL27348144 | 0.77 | PNMT (0.45) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL944866 | 0.77 | PNMT (0.33) | PNMTNPC1RAB9APGRCYP17A1 | |
| Hydrochloric Acid SCHEMBL7913247 | 0.77 | PNMT (0.36) | PNMTNPC1RAB9APGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL27650656 | 0.77 | PNMT (0.36) | PNMTNPC1RAB9APGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL4447246 | 0.77 | DRD2 (0.38) | PNMTNPC1RAB9APGRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422703-B1 | CATALYST AND PROCESS FOR THE POLYMERIZATION AND COPOLYMERIZATION OF ALPHA-OLEFINS | Enichem Anic S.r.l. (IT) | 1993-06-30 | — | — | EP | claimed |
| US-5128295-A | Hafnium-titanium-zirconium compound with trialkylaluminum and distannoxane | ENICHEM ANIC S.P.A. (IT) | 1992-07-07 | — | — | US | claimed |
| EP-0422703-A1 | Catalyst and process for the polymerization and copolymerization of alpha-olefins | Enichem Anic S.r.l. (IT) | 1991-04-17 | — | — | EP | claimed |
| JP-3217442-A | — | — | None | — | — | JP | disclosed |
| JP-2300212-A | — | — | None | — | — | JP | disclosed |
| JP-2269705-A | — | — | None | — | — | JP | disclosed |
| JP-4001210-A | — | — | None | — | — | JP | disclosed |
| JP-3255112-A | — | — | None | — | — | JP | disclosed |
| JP-3139506-A | — | — | None | — | — | JP | disclosed |
| JP-2292311-A | — | — | None | — | — | JP | disclosed |
| JP-3070713-A | — | — | None | — | — | JP | disclosed |
| EP-0422703-A1 | Catalyst and process for the polymerization and copolymerization of alpha-olefins | Enichem Anic S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| EP-0419677-A1 | SYNDIOTACTIC POLYPROPYLENE RESIN COMPOSITION | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-04-03 | — | — | EP | disclosed |
| JP-H0370713-A | COPOLYMER OF PROPYLENE AND BUTENE | MITSUI TOATSU CHEM INC | 1991-03-26 | — | — | JP | disclosed |
| EP-0414202-A2 | Novel extruded polypropylene films and sheets | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-02-27 | — | — | EP | disclosed |
| JP-H0312439-A | SYNDIOTACTIC POLYPROPYLENE RESIN COMPOSITION AND PRODUCTION THEREOF | MITSUI TOATSU CHEM INC | 1991-01-21 | — | — | JP | disclosed |
| EP-0403866-A1 | Novel Poly-alfa-olefins | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-12-27 | — | — | EP | disclosed |
| JP-H02300212-A | PRODUCTION OF SYNDIOTACTIC POLYPROPYLENE | MITSUI TOATSU CHEM INC | 1990-12-12 | — | — | JP | disclosed |
| JP-H02292311-A | PRODUCTION OF SYNDIOTACTIC POLYPROPYLENE | MITSUI TOATSU CHEM INC | 1990-12-03 | — | — | JP | disclosed |
| JP-H02269705-A | POLYMERIZATION OF ETHYLENE | MITSUI TOATSU CHEM INC | 1990-11-05 | — | — | JP | disclosed |