Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 7/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710275 | 0.82 | PSMB1 (0.40) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL1710539 | 0.81 | DUT (0.36) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL1500330 | 0.79 | PSMB1 (0.42) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL20786907 | 0.79 | HTR7 (0.42) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL1710236 | 0.78 | ALDH1A1 (0.35) | PSMB1PSMB5POLBGAANPSR1 | |
| SCHEMBL20786879 | 0.77 | TNF (0.51) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL1500208 | 0.72 | PSMB1 (0.43) | TNFPSMB1PSMB5POLBKDM4E | |
| SCHEMBL18953783 | 0.71 | TNF (0.43) | TNF | |
| SCHEMBL20786908 | 0.71 | ITGB3 (0.51) | PSMB1PSMB5POLBKDM4E | |
| SCHEMBL20808938 | 0.70 | PSMB1 (0.48) | PSMB1PSMB5POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |
| US-20100099665-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099665-A1 | ISOQUINOLINONE DERIVATIVES | SDHA, NQO1, CYP3A5 | TNF 1765/4885PSMB1 3437/4885PSMB5 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.