SCHEMBL239637

SCHEMBL239637

Nc1ccc(Br)c(F)c1N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.38
KCNH2 Q12809 2/20 0.38
KDM1B Q8NB78 2/20 0.38
AXL P30530 1/20 0.34
ALDH1A1 P00352 3/20 0.33
MAPT P10636 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
POLB P06746 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
APAF1 O14727 1/20 0.32
TDP2 O95551 1/20 0.32
CASP3 P42574 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
CA1 P00915 3/20 0.32
CA2 P00918 3/20 0.32
CA9 Q16790 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29386666 1.00 KDM1A (0.38) KDM1AKCNH2KDM1BAXLALDH1A1
SCHEMBL441345 0.81 KDM1A (0.43) KDM1AKCNH2KDM1BAXLALDH1A1
SCHEMBL1494553 0.79 KDM1A (0.38) KDM1AKCNH2KDM1BMAPTCA1
SCHEMBL30216060 0.79 KDM1A (0.38) KDM1AKCNH2KDM1BMAPTCA1
SCHEMBL38652629 0.79 AXL (0.34) KDM1AKCNH2KDM1BAXLALDH1A1
SCHEMBL13070003 0.77 ALDH1A1 (0.39) ALDH1A1MAPTMEN1KMT2AHTT
SCHEMBL1224150 0.75 CDC7 (0.36) KDM1AKCNH2KDM1BCA1CA2
SCHEMBL150967 0.75 CYP3A4 (0.40) KDM1AKCNH2KDM1BAXLALDH1A1
SCHEMBL21815082 0.75 KDM1A (0.35) KDM1AKCNH2KDM1BAXLALDH1A1
SCHEMBL20870374 0.75 KDM1A (0.35) KDM1AKCNH2KDM1BAXLALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114702646-B Fluorenyl-biphenyl type epoxy material with high insulating property and preparation method thereof 合肥工业大学 2024-05-31 CN claimed
CN-114702646-A Fluorenyl-biphenyl epoxy material with high insulating property and preparation method thereof 合肥工业大学 2022-07-05 CN claimed
CN-111097294-A Preparation method of nanofiltration membrane for reclaimed water treatment 宁波水艺膜科技发展有限公司 2020-05-05 CN claimed
EP-4288426-B1 QUINOXALINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS INC (US) 2026-02-04 EP disclosed
EP-4676926-A1 BICYCLIC HETEROARYL COMPOUNDS FOR USE AS GPR35 MODULATORS ThirtyFiveBio Limited (GB) 2026-01-14 EP disclosed
EP-4452256-B1 METHODS OF TREATING BRAIN TUMOURS AND NEUROBLASTOMAS ASTRAZENECA AB (SE) 2025-12-10 EP disclosed
US-12492188-B2 1H-benzo[D]imidazole derivatives as TLR9 inhibitors for the treatment of fibrosis BRISTOL-MYERS SQUIBB COMPANY (US) 2025-12-09 US disclosed
US-20250368615-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2025-12-04 US disclosed
US-12421208-B2 Chemical compounds ASTRAZENECA AB (SE) 2025-09-23 US disclosed
US-20250282782-A1 PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS GENZYME CORP (US) 2025-09-11 US disclosed
EP-4225441-B1 NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM ENDOGENA THERAPEUTICS INC (US) 2025-06-11 EP disclosed
US-20110092415-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-04-21 US disclosed
WO-2010135524-A1 BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES EXELIXIS, INC. (US) 2010-11-25 WO disclosed
US-20100298290-A1 Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture EXELIXIS, INC. (US) 2010-11-25 US disclosed
US-20100222345-A1 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION 2010-09-02 US disclosed
US-20100222345-A1 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION 2010-09-02 US disclosed
US-20100222345-A1 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION 2010-09-02 US disclosed
EP-2049481-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SmithKline Beecham Corporation (US) 2009-04-22 EP disclosed
WO-2008021851-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION (US) 2008-02-21 WO disclosed
WO-2008021851-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION (US) 2008-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298290-A1 Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture MTOR, RICTOR, PIK3CA KDM1A 1161/4885KCNH2 1236/4885KDM1B 896/4885
US-20250368615-A1 CHEMICAL COMPOUNDS CYP11B2, CYP11B1, CYP4B1 KDM1A 491/4885KCNH2 926/4885KDM1B 301/4885
US-12421208-B2 Chemical compounds CYP11B2, CYP11B1, CYP4B1 KDM1A 491/4885KCNH2 926/4885KDM1B 301/4885
US-12492188-B2 1H-benzo[D]imidazole derivatives as TLR9 inhibitors for the treatment of fibrosis TLR9, TLR1, TLR7 KDM1A 246/4885KCNH2 1424/4885KDM1B 310/4885
US-20250282782-A1 PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS PTPN5, PTPN2, PTPRJ KDM1A 1569/4885KCNH2 3991/4885KDM1B 1112/4885
US-20110092415-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KDM1A 3505/4885KCNH2 4523/4885KDM1B 3412/4885
US-20100222345-A1 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS OPRL1, OPRM1, OPRK1 KDM1A 4009/4885KCNH2 909/4885KDM1B 3916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.